Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Fabrizio Fabrizi, Simona Verdesca, Piergiorgio Messa, Paul Martin

Research output: Contribution to journalArticlepeer-review


Background and Rationale: Chronic kidney disease and hepatitis C virus are prevalent in the general population worldwide, and controversy exists about the impact of HCV infection on the development and progression of kidney disease. Design: A systematic review of the published medical literature was made to assess whether positive anti-HCV serologic status plays an independent impact on the development of chronic kidney disease in the adult general population. We used a random-effects model to generate a summary estimate of the relative risk of chronic kidney disease (defined by reduced glomerular filtration rate or detectable proteinuria) with HCV across the published studies. Meta-regression and stratified analysis were also conducted. Results: Twenty-three studies (n = 2,842,421 patients) were eligible, and separate meta-analyses were performed according to the outcome. Pooling results of longitudinal studies (n = 9; 1,947,034 unique patients) demonstrated a relationship between positive HCV serologic status and increased incidence of chronic kidney disease, the summary estimate for adjusted hazard ratio was 1.43 (95 % confidence interval 1.23; 1.63, P = 0.0001), and between-studies heterogeneity was noted (P value by Q test

Original languageEnglish
Pages (from-to)3801-3813
Number of pages13
JournalDigestive Diseases and Sciences
Issue number12
Publication statusPublished - Dec 1 2015


  • Adult population
  • Chronic kidney disease
  • Hepatitis C
  • Meta-analysis
  • Proteinuria

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology


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