Hepatitis C virus micro-elimination: Where do we stand?

Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla

Research output: Contribution to journalReview articlepeer-review


Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviral treatments, has been promoted by the World Health Organization. This achievement is not attainable, however, particularly after the 2020 pandemic of the coronavirus disease 2019. Consequently, the more realistic objective of eliminating HCV from population segments for which targeted strategies of prevention and treatment are easily attained has been promoted in Europe, as a valid alternative. The underlying idea is that micro-elimination will ultimately lead to macro-elimination. The micro-elimination strategy may target different specific populations and at-risk groups. Different settings, including prisons and hospitals, have also been identified as micro-elimination scenarios. In addition, dedicated micro-elimination strategies have been designed that are tailored at the geographical level according to HCV epidemiology and individual country's income. The main elements of a valid and successful micro-elimination project are reliable epidemiological data and active involvement of all the stakeholders. Community involvement represents another essential component for a successful program.

Original languageEnglish
Pages (from-to)1728-1737
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number16
Publication statusPublished - Apr 28 2021


  • Hepatitis C virus antibodies; Hepatitis C virus elimination; Hepatitis C virus epidemiology; Hepatitis C virus RNA; Hepatitis C virus diagnosis; Hepatitis C virus infection

ASJC Scopus subject areas

  • Gastroenterology


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