Hepatitis C virus, mitochondria and auto/mitophagy: Exploiting a host defense mechanism

Vitalba Ruggieri, Carmela Mazzoccoli, Valerio Pazienza, Angelo Andriulli, Nazzareno Capitanio, Claudia Piccoli

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus (HCV) is the major reason for liver transplantation and the main cause of liver-related morbidity and mortality in a great number of countries. As for the other viruses, this pathogen interferes in more than one process and in more than one way with host cell biology. A mounting body of evidence points, in particular, toward the drastic alterations of mitochondrial physiology and functions that virus is able to induce, albeit the mechanisms have partly remained elusive. Role of the mitochondria in immunity and in quality control systems, as autophagy, as well as the strategies that HCV has evolved to evade and even to manipulate mitochondrial surveillance for its benefit, highlights the importance of deepening the mechanisms that modulate this virus-mitochondrion interaction, not only to intensify our knowledge of the HCV infection pathogenesis but also to design efficient antiviral strategies.

Original languageEnglish
Pages (from-to)2624-2633
Number of pages10
JournalWorld Journal of Gastroenterology
Volume20
Issue number10
DOIs
Publication statusPublished - Mar 14 2014

Keywords

  • Autophagy
  • Hepatitis C virus
  • Immunity
  • Mitochondrial dysfunctions
  • Mitophagy

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

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