Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations

C Visco, J Wang, MC Tisi, L Deng, Emanuele S G d'Amore, A Tzankov, S Montes-Moreno, K Dybkær, G Bhagat, ED Hsi, JH Van Krieken, M Ponzoni, AJM Ferreri, MB Møller, MA Piris, LJ Medeiros, ZY Xu-Monette, KH Young

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Abstract

Background:The clinical presentation of patients with hepatitis C virus (HCV)-positive diffuse large B-cell lymphoma (DLBCL) is different from their HCV-negative counterparts, but the underlying molecular and pathological characteristics are largely under investigated. The virus has a role in lymphomagenesis, as witnessed by the curative potential of antiviral therapy in HCV-related low-grade B-cell lymphomas.Methods:We performed a case-control study including 44 HCV-positive cases of de novo DLBCL, comparing them with 132 HCV-negative patients as controls (ratio 3 to 1). Cases and controls were matched for age, lactate dehydrogenase level and international prognostic index at presentation. Patients were studied by gene expression profiling for cell-of-origin determination and to perform differential expression analysis between groups, fluorescence in-situ hybridisation and immunohistochemistry for MYC, BCL2 and BCL6, TP53 mutations, and diagnostic specimens reviewed to exclude transformation from low-grade lymphoma.Results:Compared to the HCV-negative controls, patients with HCV-positive de novo DLBCL had differential expression of genes that regulate innate immune response and modulate apoptotic pathways, have higher proliferative index, and lack BCL2 translocations.Conclusions:HCV-positive DLBCL have distinct molecular and pathological features compared to the HCV-negative counterparts. © 2017 Cancer Research UK. All rights reserved.
Original languageEnglish
Pages (from-to)1685-1688
Number of pages4
JournalBritish Journal of Cancer
Volume117
Issue number11
DOIs
Publication statusPublished - 2017

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Visco, C., Wang, J., Tisi, MC., Deng, L., d'Amore, E. S. G., Tzankov, A., Montes-Moreno, S., Dybkær, K., Bhagat, G., Hsi, ED., Van Krieken, JH., Ponzoni, M., Ferreri, AJM., Møller, MB., Piris, MA., Medeiros, LJ., Xu-Monette, ZY., & Young, KH. (2017). Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations. British Journal of Cancer, 117(11), 1685-1688. https://doi.org/10.1038/bjc.2017.345