Abstract
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.
Original language | English |
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Pages (from-to) | 1953-1965 |
Number of pages | 13 |
Journal | World Journal of Gastroenterology |
Volume | 22 |
Issue number | 6 |
DOIs | |
Publication status | Published - Feb 14 2016 |
Keywords
- Apolipoproteins
- Hepatitis C virus
- Lipid metabolism
- Lipoproteins
- Review
ASJC Scopus subject areas
- Gastroenterology