Hepatitis C virus relies on lipoproteins for its life cycle

Germana Grassi; Giorgia Di Caprio; Gian Maria Fimia; Giuseppe Ippolito; Marco Tripodi; Tonino Alonzi

doi:10.3748/wjg.v22.i6.1953

Hepatitis C virus relies on lipoproteins for its life cycle

Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

Original language	English
Pages (from-to)	1953-1965
Number of pages	13
Journal	World Journal of Gastroenterology
Volume	22
Issue number	6
DOIs	https://doi.org/10.3748/wjg.v22.i6.1953
Publication status	Published - Feb 14 2016

Keywords

Apolipoproteins
Hepatitis C virus
Lipid metabolism
Lipoproteins
Review

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.3748/wjg.v22.i6.1953

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Cite this

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AU - Fimia, Gian Maria

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AU - Tripodi, Marco

AU - Alonzi, Tonino

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AB - Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

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