Hepatitis C virus relies on lipoproteins for its life cycle

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

Original languageEnglish
Pages (from-to)1953-1965
Number of pages13
JournalWorld Journal of Gastroenterology
Volume22
Issue number6
DOIs
Publication statusPublished - Feb 14 2016

Keywords

  • Apolipoproteins
  • Hepatitis C virus
  • Lipid metabolism
  • Lipoproteins
  • Review

ASJC Scopus subject areas

  • Gastroenterology

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