Hepatitis C virus RNA in serum of blood donors with or without elevated transaminase levels

R. Romeo, V. Thiers, F. Driss, P. Berthelot, B. Nalpas, C. Brechot

Research output: Contribution to journalArticlepeer-review

Abstract

The pattern of hepatitis C virus (HCV) viremia in blood donors who are positive for antibody to HCV (anti-HCV) according to the level of transaminase activity is unclear. A polymerase chain reaction-based HCV RNA detection method was used to study two clearly defined groups of anti-HCV- positive blood donors with repeatedly normal (n=27) and elevated (n=17) alanine aminotransferase (ALT) levels. HCV RNA was detected in only 4 of 27 blood donors with normal ALT values and 15 of 17 with elevated ALT values. These results indicate that anti-HCV-positive blood donors with normal ALT levels constitute a heterogeneous group, as HCV viremia is detectable in only a small proportion of cases. Polymerase chain reaction should be useful in the surveillance of anti-HCV-positive blood donors with normal ALT levels, by identifying those who might benefit from further investigation and treatment.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalTransfusion
Volume33
Issue number8
Publication statusPublished - 1993

Keywords

  • ALT = alanine aminotransferase
  • anti-HCV = antibody to HCV
  • ELISA = enzyme-linked immunosorbent assay
  • HCV = hepatitis C virus
  • PBMCs = peripheral blood mononuclear cells
  • PCR = polymerase chain reaction
  • RIBA = recombinant immunoblotassay

ASJC Scopus subject areas

  • Immunology
  • Hematology

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