TY - JOUR
T1 - Hepatitis delta virus
T2 - Making the point from virus isolation up to 2014
AU - Romeo, Raffaella
AU - Perbellini, Riccardo
PY - 2015
Y1 - 2015
N2 - Chronic infection with hepatitis delta virus (HDV) has lately regained clinical importance because of the recent evidence of increasing prevalence in several European countries, due to immigration from highly endemic areas. HDV requires the mandatory presence of hepatitis B virus (HBV) for propagation to hepatocytes. It is transmitted by the same routes of HBV and it can be acquired either by co-infection (simultaneous transmission of the two viruses) or super-infection (acquisition of HDV by an already chronic carrier of HBV). As a consequence, every HBV carrier is potentially at risk for HDV superinfection. Since the clinical course of superinfection can be severe, early diagnosis of HDV infection is necessary.
AB - Chronic infection with hepatitis delta virus (HDV) has lately regained clinical importance because of the recent evidence of increasing prevalence in several European countries, due to immigration from highly endemic areas. HDV requires the mandatory presence of hepatitis B virus (HBV) for propagation to hepatocytes. It is transmitted by the same routes of HBV and it can be acquired either by co-infection (simultaneous transmission of the two viruses) or super-infection (acquisition of HDV by an already chronic carrier of HBV). As a consequence, every HBV carrier is potentially at risk for HDV superinfection. Since the clinical course of superinfection can be severe, early diagnosis of HDV infection is necessary.
KW - Epidemiology
KW - Hepatitis delta virus
KW - Natural history
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84943427382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943427382&partnerID=8YFLogxK
U2 - 10.4254/wjh.v7.i22.2389
DO - 10.4254/wjh.v7.i22.2389
M3 - Article
AN - SCOPUS:84943427382
VL - 7
SP - 2389
EP - 2395
JO - World Journal of Hepatology
JF - World Journal of Hepatology
SN - 1948-5182
IS - 22
ER -