Hepatitis delta virus: Making the point from virus isolation up to 2014

Raffaella Romeo, Riccardo Perbellini

Research output: Contribution to journalArticlepeer-review


Chronic infection with hepatitis delta virus (HDV) has lately regained clinical importance because of the recent evidence of increasing prevalence in several European countries, due to immigration from highly endemic areas. HDV requires the mandatory presence of hepatitis B virus (HBV) for propagation to hepatocytes. It is transmitted by the same routes of HBV and it can be acquired either by co-infection (simultaneous transmission of the two viruses) or super-infection (acquisition of HDV by an already chronic carrier of HBV). As a consequence, every HBV carrier is potentially at risk for HDV superinfection. Since the clinical course of superinfection can be severe, early diagnosis of HDV infection is necessary.

Original languageEnglish
Pages (from-to)2389-2395
Number of pages7
JournalWorld Journal of Hepatology
Issue number22
Publication statusPublished - 2015


  • Epidemiology
  • Hepatitis delta virus
  • Natural history
  • Treatment

ASJC Scopus subject areas

  • Hepatology


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