Hepatitis E in Children

A Position Paper by the ESPGHAN Hepatology Committee

Björn Fischler, Ulrich Baumann, Antal Dezsofi, Nedim Hadzic, Loreto Hierro, Jörg Jahnel, Valérie McLin, Valerio Nobili, Francoise Smets, Henkjan Verkade, Dominique Debray

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND:: Hepatitis E virus (HEV) is endemic in large parts of the developing world. Waterborne transmission of genotypes 1 or 2 commonly causes acute hepatitis, which is usually self limited in healthy individuals. In addition, acute HEV infections also occur outside endemic areas, mostly related to foodborne transmission of HEV genotype 3. A growing number of publications in the last decade have reported chronic infection progressing to cirrhosis in immunosuppressed patients. It has also been suggested that HEV transmission may occur via contaminated blood products. This publication aims to provide recommendations for diagnosis, prevention and treatment of HEV infection, particularly in children after solid organ transplantation (SOT). METHODS:: A systematic PubMed literature search on HEV infection from 1990 to January 2016 was performed focusing on paediatric studies. The existing body of evidence was reviewed and recommendations were agreed upon following discussion and unanimous agreement by all members of the ESPGHAN Hepatology Committee during a consensus meeting in January 2016. In the absence of randomized controlled studies these recommendations were considered to be expert opinions. KEY RECOMMENDATIONS ARE: : Immunocompetent children with increased transaminases and/or extrahepatic manifestations should be considered for testing for evidence of HEV infection. Immunocompromised children with increased aminotransferases should be repeatedly tested for HEV and may require therapeutic intervention.

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
Publication statusAccepted/In press - Apr 4 2016

Fingerprint

Hepatitis E
Hepatitis E virus
Gastroenterology
Virus Diseases
Transaminases
Genotype
Expert Testimony
Organ Transplantation
PubMed
Hepatitis
Publications
Fibrosis
Pediatrics

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Fischler, B., Baumann, U., Dezsofi, A., Hadzic, N., Hierro, L., Jahnel, J., ... Debray, D. (Accepted/In press). Hepatitis E in Children: A Position Paper by the ESPGHAN Hepatology Committee. Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/MPG.0000000000001231

Hepatitis E in Children : A Position Paper by the ESPGHAN Hepatology Committee. / Fischler, Björn; Baumann, Ulrich; Dezsofi, Antal; Hadzic, Nedim; Hierro, Loreto; Jahnel, Jörg; McLin, Valérie; Nobili, Valerio; Smets, Francoise; Verkade, Henkjan; Debray, Dominique.

In: Journal of Pediatric Gastroenterology and Nutrition, 04.04.2016.

Research output: Contribution to journalArticle

Fischler, B, Baumann, U, Dezsofi, A, Hadzic, N, Hierro, L, Jahnel, J, McLin, V, Nobili, V, Smets, F, Verkade, H & Debray, D 2016, 'Hepatitis E in Children: A Position Paper by the ESPGHAN Hepatology Committee', Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/MPG.0000000000001231
Fischler, Björn ; Baumann, Ulrich ; Dezsofi, Antal ; Hadzic, Nedim ; Hierro, Loreto ; Jahnel, Jörg ; McLin, Valérie ; Nobili, Valerio ; Smets, Francoise ; Verkade, Henkjan ; Debray, Dominique. / Hepatitis E in Children : A Position Paper by the ESPGHAN Hepatology Committee. In: Journal of Pediatric Gastroenterology and Nutrition. 2016.
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