Hepatitis G virus infection in intravenous drug users with or without human immunodeficiency virus infection

N. Campo, R. Brizzolara, N. Sinelli, F. Puppo, A. Campelli, F. Indiveri, A. Picciotto

Research output: Contribution to journalArticle

Abstract

Background/Aims: To evaluate the HGV infection prevalence in a group of intravenous drug users with or without human immunodeficiency virus coinfection. Methodology: We studied 57 patients (48 males and 9 females) who were either previous or still ongoing intravenous drug users. Thirty-seven patients were HIV+ve, 55 patients were anti-HCV+ve and 3 patients were HBsAg chronic carriers. Patient sera were tested for HGV-RNA, anti-E2, qualitative and quantitative HCV-RNA as well as for HCV genotypes. Moreover, the ALT level was checked in the serum sample of each patient. Results: We found a high prevalence (35/57; 61.4%) of HGV infection in our patients. HGV-RNA was detected in 16 out of the 57 intravenous drug users (28%). In particular HGV-RNA was positive in 12 out of the 37 HIV+ve patients (32.4%) and in 4 out of the 20 HIV-ve patients (20%). Anti-E2 were detected in 19 out of the 57 patients (33.3%) with greater prevalence among HIV-ve subjects (12/20; 60%) compared to HIV+ve group (7/37; 18.9%). This resulting difference was statistically significant (P

Original languageEnglish
Pages (from-to)1385-1388
Number of pages4
JournalHepato-Gastroenterology
Volume47
Issue number35
Publication statusPublished - 2000

Keywords

  • Anti-E2
  • Hepatitis C virus
  • Hepatitis G virus
  • HGV-RNA
  • HIV infection
  • Intravenous drug users

ASJC Scopus subject areas

  • Gastroenterology

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    Campo, N., Brizzolara, R., Sinelli, N., Puppo, F., Campelli, A., Indiveri, F., & Picciotto, A. (2000). Hepatitis G virus infection in intravenous drug users with or without human immunodeficiency virus infection. Hepato-Gastroenterology, 47(35), 1385-1388.