Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy

Silvia Franceschi, Maurizio Montella, Jerry Polesel, Carlo La Vecchia, Anna Crispo, Luigino Dal Maso, Pietro Casarin, Francesco Izzo, Luigi G. Tommasi, Isabelle Chemin, Christian Trépo, Marina Crovatto, Renato Talamini

Research output: Contribution to journalArticlepeer-review


Mortality rates of hepatocellular carcinoma (HCC) are high in Italy compared with other Western countries. To elucidate further the role of hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol drinking, and tobacco smoking in the etiology of HCC, we carried out a hospital-based case-control study in two areas of Italy: the province of Pordenone in the Northeast and the town of Naples in the South. A total of 229 HCC cases (median age, 66 years) and 431 controls (median age, 65 years) answered a questionnaire and provided blood samples between 1999 and 2002. Odds ratios (OR), percent attributable risks, and corresponding 95% confidence intervals were computed using unconditional multiple logistic regression. ORs for hepatitis B surface antigen (HBsAg) positive versus HBsAg negative and for anti-HCV antibody positive versus anti-HCV antibody negative were 20.2 and 15.6, respectively. Positivity for both markers was associated with an OR of 51.6. Sensitive molecular techniques applied to sera in a subset of HCC cases disclosed a very small number of occult hepatites. Maximal lifetime alcohol intake of ≥35 versus

Original languageEnglish
Pages (from-to)683-689
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Issue number4
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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