Hepatoblastoma state of the art: Pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation

Rebecka L. Meyers, Greg Tiao, Jean De Ville De Goyet, Riccardo Superina, Daniel C. Aronson

Research output: Contribution to journalArticle

Abstract

Purpose of review: This is part two of a two-part state of the art-hepatoblastoma. International hepatoblastoma specialists were brought together to highlight advances, controversies, and future challenges in the treatment of this rare pediatric tumor. Recent findings: Pretreatment extent of disease (PRETEXT) is a grouping system introduced as part of the multicenter international childhood liver tumors strategy group, SIOPEL-1, study in 1990. The system has been refined over the ensuing years and has now come to be adopted for risk stratification by all of the major pediatric liver tumor multicenter trial groups. PRETEXT is being intensively studied in the current ChildrenÊs Oncology Group (COG) AHEP-0731 trial in an attempt to validate interobserver reproducibility and ability to monitor response to neoadjuvant chemotherapy, and determine surgical resectability. PRETEXT is now used to identify those patients who are at risk for having an unresectable tumor and who should be referred to a liver specialty center with transplant capability early in their treatment schema. Summary: International collaborative efforts in hepatoblastoma have led to increased refinements in the use of the PRETEXT and post-treatment extent to define prognosis and surgical resectability. PRETEXT criteria which suggest a possible need for liver transplantation are discussed in detail.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalCurrent Opinion in Pediatrics
Volume26
Issue number1
DOIs
Publication statusPublished - Feb 2014

Keywords

  • hepatoblastoma
  • pediatric liver transplantation
  • POST-TEXT
  • PRETEXT
  • surgical resection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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