Hepatocellular carcinoma and cirrhosis in 746 patients: Long-term results of percutaneous ethanol injection

T. Livraghi, A. Giorgio, G. Marin, A. Salmi, I. De Sio, L. Bolondi, M. Pompili, F. Brunello, S. Lazzaroni, G. Torzilli, A. Zucchi

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Abstract

PURPOSE: To define indications for percutaneous ethanol injection (PEI) in patients with hepatocellular carcinoma (HCC) and cirrhosis. MATERIALS AND METHODS: Survival rates were determined in 746 patients who had undergone PEI (567 men, 179 women; mean age, 64.3 years; mean follow-up, 36 months). RESULTS: In patients with Child A (n = 293), B (n = 149), or C (n = 20) cirrhosis and single HCCs 5 cm or smaller, the 3-5-year survival rate was 47%-79%, 29%-63%, and 0%-12%, respectively. In patients with Child A cirrhosis, it was 36%-68% for multiple HCCs (n = 121), 30%-53% for single HCCs larger than 5 cm (n = 28), and 0%-16% for advanced HCC (n = 16). Treatment was associated with a 1.7% rate of severe complications and a 0.1% mortality rate. CONCLUSION: PEI proved safe, effective, and repeatable and had a low cost. Survival after PEI was comparable to that after surgery, probably because of a balancing between greater radicality of surgery and absence of early mortality and liver damage of PEI.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalRadiology
Volume197
Issue number1
Publication statusPublished - 1995

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Keywords

  • Alcohol
  • Liver neoplasms, therapy
  • Liver, interventional procedure

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Livraghi, T., Giorgio, A., Marin, G., Salmi, A., De Sio, I., Bolondi, L., Pompili, M., Brunello, F., Lazzaroni, S., Torzilli, G., & Zucchi, A. (1995). Hepatocellular carcinoma and cirrhosis in 746 patients: Long-term results of percutaneous ethanol injection. Radiology, 197(1), 101-108.