Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: A closer look at the role of siderosis

Joseph E. Maakaron, Maria Domenica Cappellini, Giovanna Graziadei, Jad Bou Ayache, Ali T. Taher

Research output: Contribution to journalArticle


Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalAnnals of Hepatology
Issue number1
Publication statusPublished - Jan 2013



  • Hepatocellular carcinoma
  • Iron overload
  • Liver iron concentration
  • Risk factor
  • Thalassemia intermedia

ASJC Scopus subject areas

  • Hepatology

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