TY - JOUR
T1 - Hepatocellular carcinoma in patients with cirrhosis
T2 - Qualitative comparison of gadobenate dimeglumine-enhanced MR imaging and multiphasic 64-section CT
AU - Marin, Daniele
AU - Di Martino, Michele
AU - Guerrisi, Antonino
AU - De Filippis, Gianmaria
AU - Rossi, Massimo
AU - Corradini, Stefano Ginanni
AU - Masciangelo, Raffaele
AU - Catalano, Carlo
AU - Passariello, Roberto
PY - 2009/4
Y1 - 2009/4
N2 - Purpose: To prospectively investigate whether combined interpretation of dynamic and hepatobiliary phase magnetic resonance (MR) images can improve the accuracy of gadobenate dimeglumine-enhanced MR imaging in the detection of hepatocellular carcinoma (HCC) compared with either dynamic MR or multiphasic multidetector computed tomographic (CT) images alone. Materials and Methods: Institutional review board approval and informed patient consent were obtained. Fifty-two patients (39 men, 13 women; mean age, 68 years; range, 38-81 years) suspected of having HCC underwent gadobenate dimeglumine-enhanced MR imaging and multiphasic 64-section multidetector CT. Images were qualitatively analyzed independently by three observers in three separate reading sessions. The alternating free-response receiver operating characteristic (AFROC) method was used to analyze the results. Differences in sensitivity and positive predictive values were calculated at a statistical significance of P <.05. Results: A total of 67 HCCs were detected in 36 patients. The mean area under the AFROC curve (Az) was significantly higher for either the combined interpretation of dynamic and hepatobiliary phase MR images (Az = 0.95) or dynamic MR images alone (0.91) than for CT images (0.77) (P = .01 for both comparisons). The mean sensitivity of combined interpretation of MR images (0.72) was significantly higher than those of dynamic MR images alone (0.63) and multidetector CT images (0.61) (P = .008 and .001, respectively). The mean positive predictive value was not significantly different among the three imaging sets. Conclusion: The combined interpretation of dynamic and hepatobiliary phase MR images improves diagnostic accuracy of gadobenate dimeglumine-enhanced MR imaging for the detection of HCC compared with either dynamic MR or multiphasic multidetector CT images alone.
AB - Purpose: To prospectively investigate whether combined interpretation of dynamic and hepatobiliary phase magnetic resonance (MR) images can improve the accuracy of gadobenate dimeglumine-enhanced MR imaging in the detection of hepatocellular carcinoma (HCC) compared with either dynamic MR or multiphasic multidetector computed tomographic (CT) images alone. Materials and Methods: Institutional review board approval and informed patient consent were obtained. Fifty-two patients (39 men, 13 women; mean age, 68 years; range, 38-81 years) suspected of having HCC underwent gadobenate dimeglumine-enhanced MR imaging and multiphasic 64-section multidetector CT. Images were qualitatively analyzed independently by three observers in three separate reading sessions. The alternating free-response receiver operating characteristic (AFROC) method was used to analyze the results. Differences in sensitivity and positive predictive values were calculated at a statistical significance of P <.05. Results: A total of 67 HCCs were detected in 36 patients. The mean area under the AFROC curve (Az) was significantly higher for either the combined interpretation of dynamic and hepatobiliary phase MR images (Az = 0.95) or dynamic MR images alone (0.91) than for CT images (0.77) (P = .01 for both comparisons). The mean sensitivity of combined interpretation of MR images (0.72) was significantly higher than those of dynamic MR images alone (0.63) and multidetector CT images (0.61) (P = .008 and .001, respectively). The mean positive predictive value was not significantly different among the three imaging sets. Conclusion: The combined interpretation of dynamic and hepatobiliary phase MR images improves diagnostic accuracy of gadobenate dimeglumine-enhanced MR imaging for the detection of HCC compared with either dynamic MR or multiphasic multidetector CT images alone.
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U2 - 10.1148/radiol.2511080400
DO - 10.1148/radiol.2511080400
M3 - Article
C2 - 19332848
AN - SCOPUS:64949091694
VL - 251
SP - 85
EP - 95
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 1
ER -