Hepatocellular carcinoma in the thalassaemia syndromes

Caterina Borgna-Pignatti; Gianluca Vergine; Turi Lombardo; Maria Domenica Cappellini; Paolo Cianciulli; Aurelio Maggio; Disma Renda; Maria Eliana Lai; Antonella Mandas; Gianluca Forni; Antonio Piga; Maria Grazia Bisconte

doi:10.1046/j.1365-2141.2003.04732.x

Hepatocellular carcinoma in the thalassaemia syndromes

Caterina Borgna-Pignatti, Gianluca Vergine, Turi Lombardo, Maria Domenica Cappellini, Paolo Cianciulli, Aurelio Maggio, Disma Renda, Maria Eliana Lai, Antonella Mandas, Gianluca Forni, Antonio Piga, Maria Grazia Bisconte

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 ± 11 years and the mean serum ferritin was 1764 ± 1448 μg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.

Original language	English
Pages (from-to)	114-117
Number of pages	4
Journal	British Journal of Haematology
Volume	124
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04732.x
Publication status	Published - Jan 2004

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Keywords

Cirrhosis
Hepatitis C
Hepatocellular carcinoma
Iron overload
Thalassaemia

ASJC Scopus subject areas

Hematology

Cite this

Borgna-Pignatti, C., Vergine, G., Lombardo, T., Cappellini, M. D., Cianciulli, P., Maggio, A., Renda, D., Lai, M. E., Mandas, A., Forni, G., Piga, A., & Bisconte, M. G. (2004). Hepatocellular carcinoma in the thalassaemia syndromes. British Journal of Haematology, 124(1), 114-117. https://doi.org/10.1046/j.1365-2141.2003.04732.x

Hepatocellular carcinoma in the thalassaemia syndromes. / Borgna-Pignatti, Caterina; Vergine, Gianluca; Lombardo, Turi; Cappellini, Maria Domenica; Cianciulli, Paolo; Maggio, Aurelio; Renda, Disma; Lai, Maria Eliana; Mandas, Antonella; Forni, Gianluca; Piga, Antonio; Bisconte, Maria Grazia.

In: British Journal of Haematology, Vol. 124, No. 1, 01.2004, p. 114-117.

Research output: Contribution to journal › Article

Borgna-Pignatti, Caterina ; Vergine, Gianluca ; Lombardo, Turi ; Cappellini, Maria Domenica ; Cianciulli, Paolo ; Maggio, Aurelio ; Renda, Disma ; Lai, Maria Eliana ; Mandas, Antonella ; Forni, Gianluca ; Piga, Antonio ; Bisconte, Maria Grazia. / Hepatocellular carcinoma in the thalassaemia syndromes. In: British Journal of Haematology. 2004 ; Vol. 124, No. 1. pp. 114-117.

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10.1046/j.1365-2141.2003.04732.x