Hepatocellular carcinoma in the thalassaemia syndromes

Caterina Borgna-Pignatti, Gianluca Vergine, Turi Lombardo, Maria Domenica Cappellini, Paolo Cianciulli, Aurelio Maggio, Disma Renda, Maria Eliana Lai, Antonella Mandas, Gianluca Forni, Antonio Piga, Maria Grazia Bisconte

Research output: Contribution to journalArticle


Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 ± 11 years and the mean serum ferritin was 1764 ± 1448 μg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalBritish Journal of Haematology
Issue number1
Publication statusPublished - Jan 2004



  • Cirrhosis
  • Hepatitis C
  • Hepatocellular carcinoma
  • Iron overload
  • Thalassaemia

ASJC Scopus subject areas

  • Hematology

Cite this

Borgna-Pignatti, C., Vergine, G., Lombardo, T., Cappellini, M. D., Cianciulli, P., Maggio, A., Renda, D., Lai, M. E., Mandas, A., Forni, G., Piga, A., & Bisconte, M. G. (2004). Hepatocellular carcinoma in the thalassaemia syndromes. British Journal of Haematology, 124(1), 114-117. https://doi.org/10.1046/j.1365-2141.2003.04732.x