TY - JOUR
T1 - Hepatocellular carcinoma in the thalassaemia syndromes
AU - Borgna-Pignatti, Caterina
AU - Vergine, Gianluca
AU - Lombardo, Turi
AU - Cappellini, Maria Domenica
AU - Cianciulli, Paolo
AU - Maggio, Aurelio
AU - Renda, Disma
AU - Lai, Maria Eliana
AU - Mandas, Antonella
AU - Forni, Gianluca
AU - Piga, Antonio
AU - Bisconte, Maria Grazia
PY - 2004/1
Y1 - 2004/1
N2 - Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 ± 11 years and the mean serum ferritin was 1764 ± 1448 μg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.
AB - Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 ± 11 years and the mean serum ferritin was 1764 ± 1448 μg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.
KW - Cirrhosis
KW - Hepatitis C
KW - Hepatocellular carcinoma
KW - Iron overload
KW - Thalassaemia
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U2 - 10.1046/j.1365-2141.2003.04732.x
DO - 10.1046/j.1365-2141.2003.04732.x
M3 - Article
C2 - 14675416
AN - SCOPUS:9144224804
VL - 124
SP - 114
EP - 117
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -