Hepatocyte growth factor is a regulator of monocyte-macrophage function

F. Galimi, E. Cottone, E. Vigna, N. Arena, C. Boccaccio, S. Giordano, L. Naldini, P. M. Comoglio

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Hepatocyte growth factor (HGF) is a potent paracrine mediator of stromal/epithelial interactions, which is secreted as a matrix-associated inactive precursor (pro-HGF) and locally activated by tightly controlled urokinase cleavage. It induces proliferation and motility in epithelial and endothelial cells, and plays a role in physiological and pathological processes involving invasive cell growth, such as angiogenesis and parenchymal regeneration. We now report that HGF induces directional migration and cytokine secretion in human monocytes. Monocyte activation by endotoxin and IL-1β results in the up-regulation of the HGF receptor expression and in the induction of cell-associated pro-HGF convertase activity, thus enhancing cell responsiveness to the factor. Furthermore, we provide evidence for the secretion of biologically active HGF by activated monocytes, implying an autocrine stimulation. Altogether, these data indicate that monocyte function is modulated by HGF in a paracrine/autocrine manner, and provide a new link between stromal environment and mononuclear phagocytes.

Original languageEnglish
Pages (from-to)1241-1247
Number of pages7
JournalJournal of Immunology
Volume166
Issue number2
Publication statusPublished - Jan 15 2001

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Hepatocyte Growth Factor
Monocytes
Macrophages
Proto-Oncogene Proteins c-met
Physiological Phenomena
Urokinase-Type Plasminogen Activator
Pathologic Processes
Phagocytes
Interleukin-1
Endotoxins
Regeneration
Up-Regulation
Endothelial Cells
Epithelial Cells
Cytokines
Growth
pro-hepatocyte growth factor

ASJC Scopus subject areas

  • Immunology

Cite this

Hepatocyte growth factor is a regulator of monocyte-macrophage function. / Galimi, F.; Cottone, E.; Vigna, E.; Arena, N.; Boccaccio, C.; Giordano, S.; Naldini, L.; Comoglio, P. M.

In: Journal of Immunology, Vol. 166, No. 2, 15.01.2001, p. 1241-1247.

Research output: Contribution to journalArticle

Galimi, F. ; Cottone, E. ; Vigna, E. ; Arena, N. ; Boccaccio, C. ; Giordano, S. ; Naldini, L. ; Comoglio, P. M. / Hepatocyte growth factor is a regulator of monocyte-macrophage function. In: Journal of Immunology. 2001 ; Vol. 166, No. 2. pp. 1241-1247.
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AU - Giordano, S.

AU - Naldini, L.

AU - Comoglio, P. M.

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