Abstract
Synthetic cannabinoids (SCs) are psychotropic compounds, chemically created in laboratory to mimic cannabinergic brain activity of delta-9 tetrahydrocannabinol.The consumption of these compounds for recreational purposes can lead to a variety of adverse effects on health including overdose and deaths. Increasingly popular as substances of abuse since the 2000s, SCs were produced initially to bind and study cannabinoid receptors (they also can be called synthetic cannabimimetics) failing in eliminating the psychoactive effects. Currently, SCs are misused by students and young adults as "natural products" because of their herbal aspect. Actually, these apparently innocuous recreational substances hide toxic effects to health. Reported side effects are cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, pulmonary and psychoactive including dependence and withdrawal. A few cases of SCs ingestion have also been associated with liver failure.We herein review the recent literature on the SCs toxicity with particular attention to liver damage aspects.
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | European Review for Medical and Pharmacological Sciences |
| Volume | 21 |
| Issue number | 1 |
| Publication status | Published - Jan 1 2017 |
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Keywords
- Hepatotoxicity
- Illicit use
- Synthetic cannabinoids
ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Hepatotoxicity associated to synthetic cannabinoids use. / Solimini, R.; Busardò, F. P.; Rotolo, M. C.; Ricci, Serafino; Mastrobattista, L.; Mortali, C.; Graziano, S.; Pellegrini, M.; Di Luca, N. M.; Palmi, Ilaria.
In: European Review for Medical and Pharmacological Sciences, Vol. 21, No. 1, 01.01.2017, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatotoxicity associated to synthetic cannabinoids use
AU - Solimini, R.
AU - Busardò, F. P.
AU - Rotolo, M. C.
AU - Ricci, Serafino
AU - Mastrobattista, L.
AU - Mortali, C.
AU - Graziano, S.
AU - Pellegrini, M.
AU - Di Luca, N. M.
AU - Palmi, Ilaria
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Synthetic cannabinoids (SCs) are psychotropic compounds, chemically created in laboratory to mimic cannabinergic brain activity of delta-9 tetrahydrocannabinol.The consumption of these compounds for recreational purposes can lead to a variety of adverse effects on health including overdose and deaths. Increasingly popular as substances of abuse since the 2000s, SCs were produced initially to bind and study cannabinoid receptors (they also can be called synthetic cannabimimetics) failing in eliminating the psychoactive effects. Currently, SCs are misused by students and young adults as "natural products" because of their herbal aspect. Actually, these apparently innocuous recreational substances hide toxic effects to health. Reported side effects are cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, pulmonary and psychoactive including dependence and withdrawal. A few cases of SCs ingestion have also been associated with liver failure.We herein review the recent literature on the SCs toxicity with particular attention to liver damage aspects.
AB - Synthetic cannabinoids (SCs) are psychotropic compounds, chemically created in laboratory to mimic cannabinergic brain activity of delta-9 tetrahydrocannabinol.The consumption of these compounds for recreational purposes can lead to a variety of adverse effects on health including overdose and deaths. Increasingly popular as substances of abuse since the 2000s, SCs were produced initially to bind and study cannabinoid receptors (they also can be called synthetic cannabimimetics) failing in eliminating the psychoactive effects. Currently, SCs are misused by students and young adults as "natural products" because of their herbal aspect. Actually, these apparently innocuous recreational substances hide toxic effects to health. Reported side effects are cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, pulmonary and psychoactive including dependence and withdrawal. A few cases of SCs ingestion have also been associated with liver failure.We herein review the recent literature on the SCs toxicity with particular attention to liver damage aspects.
KW - Hepatotoxicity
KW - Illicit use
KW - Synthetic cannabinoids
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M3 - Article
C2 - 28379600
AN - SCOPUS:85018308521
VL - 21
SP - 1
EP - 6
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
SN - 1128-3602
IS - 1
ER -