Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver. For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. The present review reports the information available on the hepatotoxic effects of AAS use in professional and amateur athletes.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalEuropean Review for Medical and Pharmacological Sciences
Volume21
Issue number1
Publication statusPublished - Mar 1 2017

Fingerprint

Testosterone Congeners
Athletes
Peliosis Hepatis
Urogenital System
Musculoskeletal System
Cholestasis
Dietary Supplements
Adenoma
Habits
Psychiatry
Hepatocellular Carcinoma
Central Nervous System
Skin
Liver
Health
Pharmaceutical Preparations

Keywords

  • Anabolic androgenic steroids (AAS)
  • Doping in sports
  • Hepatotoxicity
  • Illicit use

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

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title = "Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping",
abstract = "Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver. For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. The present review reports the information available on the hepatotoxic effects of AAS use in professional and amateur athletes.",
keywords = "Anabolic androgenic steroids (AAS), Doping in sports, Hepatotoxicity, Illicit use",
author = "R. Solimini and Rotolo, {M. C.} and L. Mastrobattista and C. Mortali and A. Minutillo and S. Pichini and R. Pacifici and I. Palmi",
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T1 - Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping

AU - Solimini, R.

AU - Rotolo, M. C.

AU - Mastrobattista, L.

AU - Mortali, C.

AU - Minutillo, A.

AU - Pichini, S.

AU - Pacifici, R.

AU - Palmi, I.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver. For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. The present review reports the information available on the hepatotoxic effects of AAS use in professional and amateur athletes.

AB - Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver. For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. The present review reports the information available on the hepatotoxic effects of AAS use in professional and amateur athletes.

KW - Anabolic androgenic steroids (AAS)

KW - Doping in sports

KW - Hepatotoxicity

KW - Illicit use

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