Abstract
The AA. have examined the toxic effects in rats liver caused by cyclophosphamide (12 mg/kg) chronic administration for 12 months. The toxicity for the liver is moderate and the lesions are not specific. The lesion are various histologic changes, lymphomonocytic infiltration of the peri-portal space, periportal fibrosis and interstitial haemorrhages. Similar lesions with lesser recurrence are also in not treated rats.
Translated title of the contribution | Hepatotoxicity of cyclophosphamide in the rat after prolonged treatment: a histomorphological study |
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Original language | Italian |
Pages (from-to) | 2166-2172 |
Number of pages | 7 |
Journal | Bollettino della Societa Italiana di Biologia Sperimentale |
Volume | 56 |
Issue number | 21 |
Publication status | Published - Nov 15 1980 |
ASJC Scopus subject areas
- Medicine(all)