The AA. have examined the toxic effects in rats liver caused by cyclophosphamide (12 mg/kg) chronic administration for 12 months. The toxicity for the liver is moderate and the lesions are not specific. The lesion are various histologic changes, lymphomonocytic infiltration of the peri-portal space, periportal fibrosis and interstitial haemorrhages. Similar lesions with lesser recurrence are also in not treated rats.
|Translated title of the contribution||Hepatotoxicity of cyclophosphamide in the rat after prolonged treatment: a histomorphological study|
|Number of pages||7|
|Journal||Bollettino della Societa Italiana di Biologia Sperimentale|
|Publication status||Published - Nov 15 1980|
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