Epatossicita' della ciclofosfamide dopo trattamento protratto nei ratti: studio istomorfologico.

Translated title of the contribution: Hepatotoxicity of cyclophosphamide in the rat after prolonged treatment: a histomorphological study

C. Gismondi, L. Dabove, M. Dovì, A. Picciotto, V. Savarino, R. Testa, C. Mansi

Research output: Contribution to journalArticlepeer-review

Abstract

The AA. have examined the toxic effects in rats liver caused by cyclophosphamide (12 mg/kg) chronic administration for 12 months. The toxicity for the liver is moderate and the lesions are not specific. The lesion are various histologic changes, lymphomonocytic infiltration of the peri-portal space, periportal fibrosis and interstitial haemorrhages. Similar lesions with lesser recurrence are also in not treated rats.

Translated title of the contributionHepatotoxicity of cyclophosphamide in the rat after prolonged treatment: a histomorphological study
Original languageItalian
Pages (from-to)2166-2172
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume56
Issue number21
Publication statusPublished - Nov 15 1980

ASJC Scopus subject areas

  • Medicine(all)

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