TY - JOUR
T1 - Hepcidin
T2 - Iron-hormone and anti-microbial peptide
AU - Verga Falzacappa, Maria Vittoria
AU - Muckenthaler, Martina U.
PY - 2005/12/30
Y1 - 2005/12/30
N2 - Hepcidin is a β-defensin-like peptide and a principle regulator of systemic iron homeostasis. In concordance with this dual function its expression is modulated by systemic iron requirements and in response to infectious and inflammatory stimuli. Studies of hepcidin provide novel insight into the molecular mechanisms involved in maintaining iron homeostasis in the healthy state and iron redistribution in response to chronic infections and inflammation. Furthermore, a deregulation of hepcidin may cause elevated intestinal iron absorption that hallmarks a group of frequent iron overload disorders, the Hereditary Hemochromatosis. The aim of this review is to discuss hepcidin function in iron-homeostasis under normal physiological and pathophysiological conditions.
AB - Hepcidin is a β-defensin-like peptide and a principle regulator of systemic iron homeostasis. In concordance with this dual function its expression is modulated by systemic iron requirements and in response to infectious and inflammatory stimuli. Studies of hepcidin provide novel insight into the molecular mechanisms involved in maintaining iron homeostasis in the healthy state and iron redistribution in response to chronic infections and inflammation. Furthermore, a deregulation of hepcidin may cause elevated intestinal iron absorption that hallmarks a group of frequent iron overload disorders, the Hereditary Hemochromatosis. The aim of this review is to discuss hepcidin function in iron-homeostasis under normal physiological and pathophysiological conditions.
KW - Anaemia of chronic diseases
KW - Anti-microbial peptide
KW - Hepcidin
KW - Hereditary hemochromatosis
KW - Iron metabolism
UR - http://www.scopus.com/inward/record.url?scp=28844472646&partnerID=8YFLogxK
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U2 - 10.1016/j.gene.2005.07.020
DO - 10.1016/j.gene.2005.07.020
M3 - Article
C2 - 16203112
AN - SCOPUS:28844472646
VL - 364
SP - 37
EP - 44
JO - Gene
JF - Gene
SN - 0378-1119
IS - 1-2
ER -