To better understand the role of HER-2/neu, c-myc and cyclin-A which seem to be activated in different steps of tumor cell growth, we analyzed a series of breast cancers from patients subjected to radical mastectomy with regard to HER-2/neu amplification (N=171) and expression of HER-2/neu (N=114), c- myc (N=31) and cyclin-A (N=71). Molecular evaluation demonstrated that HER- 2/neu was amplified in 20% of cases and overexpressed in 27%, and its alterations were associated with a higher proliferative activity (3H-Tdr- labeling index), although not statistically significant in patients without lymph node metastases. c-myc was overexpressed in 16% of cases and was weakly correlated to proliferation activity. Cyclin-A was overexpressed in 15% of cases and was significantly correlated to the percentage of the 3H-Tdr labeled cell fraction (p=0.002). Cyclin-A alterations were also significantly associated with well-differentiated tumors, suggesting that this gene could be involved in the control of the normal cell cycle rather than to cell proliferation during tumor growth.
|Number of pages||5|
|Journal||International Journal of Oncology|
|Publication status||Published - 1996|
- breast cancer
ASJC Scopus subject areas
- Cancer Research