HER2/neu DNA vaccination for breast tumors.

Arianna Smorlesi, Francesca Papalini, Sara Pierpaoli, Mauro Provinciali

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Several studies of DNA vaccination against HER2/neu showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumors. The DNA delivery system plays a crucial role in the success of DNA vaccination. In particular, our studies of DNA vaccination against HER2/neu tumor antigen showed that intramuscular injection of the vaccine followed by electroporation elicits an optimal protection against the development of spontaneous HER2/neu- tumors occurring in transgenic mice.

Original languageEnglish
Pages (from-to)473-485
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume423
Publication statusPublished - 2008

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Vaccination
Breast Neoplasms
DNA
Electroporation
Intramuscular Injections
Neoplasm Antigens
Transgenic Mice
Immunization
Neoplasms
Vaccines

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

HER2/neu DNA vaccination for breast tumors. / Smorlesi, Arianna; Papalini, Francesca; Pierpaoli, Sara; Provinciali, Mauro.

In: Methods in molecular biology (Clifton, N.J.), Vol. 423, 2008, p. 473-485.

Research output: Contribution to journalArticle

Smorlesi, A, Papalini, F, Pierpaoli, S & Provinciali, M 2008, 'HER2/neu DNA vaccination for breast tumors.', Methods in molecular biology (Clifton, N.J.), vol. 423, pp. 473-485.
Smorlesi, Arianna ; Papalini, Francesca ; Pierpaoli, Sara ; Provinciali, Mauro. / HER2/neu DNA vaccination for breast tumors. In: Methods in molecular biology (Clifton, N.J.). 2008 ; Vol. 423. pp. 473-485.
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