HER2/neu DNA vaccination for breast tumors.

Arianna Smorlesi, Francesca Papalini, Sara Pierpaoli, Mauro Provinciali

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies of DNA vaccination against HER2/neu showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumors. The DNA delivery system plays a crucial role in the success of DNA vaccination. In particular, our studies of DNA vaccination against HER2/neu tumor antigen showed that intramuscular injection of the vaccine followed by electroporation elicits an optimal protection against the development of spontaneous HER2/neu- tumors occurring in transgenic mice.

Original languageEnglish
Pages (from-to)473-485
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume423
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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