HER2/neu DNA vaccination for breast tumors.

Arianna Smorlesi; Francesca Papalini; Sara Pierpaoli; Mauro Provinciali

HER2/neu DNA vaccination for breast tumors.

Arianna Smorlesi, Francesca Papalini, Sara Pierpaoli, Mauro Provinciali

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Several studies of DNA vaccination against HER2/neu showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumors. The DNA delivery system plays a crucial role in the success of DNA vaccination. In particular, our studies of DNA vaccination against HER2/neu tumor antigen showed that intramuscular injection of the vaccine followed by electroporation elicits an optimal protection against the development of spontaneous HER2/neu- tumors occurring in transgenic mice.

Original language	English
Pages (from-to)	473-485
Number of pages	13
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	423
Publication status	Published - 2008

ASJC Scopus subject areas

Molecular Biology
Genetics

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abstract = "Several studies of DNA vaccination against HER2/neu showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumors. The DNA delivery system plays a crucial role in the success of DNA vaccination. In particular, our studies of DNA vaccination against HER2/neu tumor antigen showed that intramuscular injection of the vaccine followed by electroporation elicits an optimal protection against the development of spontaneous HER2/neu- tumors occurring in transgenic mice.",

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