Herbal mixtures with claimed slimming activity: Determination by TLC and HPLC of illegally added drugs

B. Parodi, G. Caviglioli, A. Bachi, S. Cafaggi, G. Romussi

Research output: Contribution to journalArticle

Abstract

A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalPharmazie
Volume48
Issue number9
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Parodi, B., Caviglioli, G., Bachi, A., Cafaggi, S., & Romussi, G. (1993). Herbal mixtures with claimed slimming activity: Determination by TLC and HPLC of illegally added drugs. Pharmazie, 48(9), 678-681.