Abstract
A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy
| Original language | English |
|---|---|
| Pages (from-to) | 678-681 |
| Number of pages | 4 |
| Journal | Pharmazie |
| Volume | 48 |
| Issue number | 9 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Molecular Medicine
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
Cite this
Herbal mixtures with claimed slimming activity : Determination by TLC and HPLC of illegally added drugs. / Parodi, B.; Caviglioli, G.; Bachi, A.; Cafaggi, S.; Romussi, G.
In: Pharmazie, Vol. 48, No. 9, 1993, p. 678-681.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Herbal mixtures with claimed slimming activity
T2 - Determination by TLC and HPLC of illegally added drugs
AU - Parodi, B.
AU - Caviglioli, G.
AU - Bachi, A.
AU - Cafaggi, S.
AU - Romussi, G.
PY - 1993
Y1 - 1993
N2 - A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy
AB - A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy
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UR - http://www.scopus.com/inward/citedby.url?scp=0027454231&partnerID=8YFLogxK
M3 - Article
VL - 48
SP - 678
EP - 681
JO - Die Pharmazie
JF - Die Pharmazie
SN - 0031-7144
IS - 9
ER -