Herbal mixtures with claimed slimming activity

Determination by TLC and HPLC of illegally added drugs

B. Parodi, G. Caviglioli, A. Bachi, S. Cafaggi, G. Romussi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalPharmazie
Volume48
Issue number9
Publication statusPublished - 1993

Fingerprint

High Pressure Liquid Chromatography
Pharmaceutical Preparations
Plant Preparations
Nylons
Distillation columns
Hypoglycemic Agents
Powders
Calibration
Antidepressive Agents
Purification
Recovery
Chemical analysis

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Parodi, B., Caviglioli, G., Bachi, A., Cafaggi, S., & Romussi, G. (1993). Herbal mixtures with claimed slimming activity: Determination by TLC and HPLC of illegally added drugs. Pharmazie, 48(9), 678-681.

Herbal mixtures with claimed slimming activity : Determination by TLC and HPLC of illegally added drugs. / Parodi, B.; Caviglioli, G.; Bachi, A.; Cafaggi, S.; Romussi, G.

In: Pharmazie, Vol. 48, No. 9, 1993, p. 678-681.

Research output: Contribution to journalArticle

Parodi, B, Caviglioli, G, Bachi, A, Cafaggi, S & Romussi, G 1993, 'Herbal mixtures with claimed slimming activity: Determination by TLC and HPLC of illegally added drugs', Pharmazie, vol. 48, no. 9, pp. 678-681.
Parodi B, Caviglioli G, Bachi A, Cafaggi S, Romussi G. Herbal mixtures with claimed slimming activity: Determination by TLC and HPLC of illegally added drugs. Pharmazie. 1993;48(9):678-681.
Parodi, B. ; Caviglioli, G. ; Bachi, A. ; Cafaggi, S. ; Romussi, G. / Herbal mixtures with claimed slimming activity : Determination by TLC and HPLC of illegally added drugs. In: Pharmazie. 1993 ; Vol. 48, No. 9. pp. 678-681.
@article{efc9255037d14659bfdf1c7df1e19202,
title = "Herbal mixtures with claimed slimming activity: Determination by TLC and HPLC of illegally added drugs",
abstract = "A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97{\%}); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV{\%} = 0.4-2.8) as well as the accuracy",
author = "B. Parodi and G. Caviglioli and A. Bachi and S. Cafaggi and G. Romussi",
year = "1993",
language = "English",
volume = "48",
pages = "678--681",
journal = "Die Pharmazie",
issn = "0031-7144",
publisher = "Govi-Verlag Pharmazeutischer Verlag GmbH",
number = "9",

}

TY - JOUR

T1 - Herbal mixtures with claimed slimming activity

T2 - Determination by TLC and HPLC of illegally added drugs

AU - Parodi, B.

AU - Caviglioli, G.

AU - Bachi, A.

AU - Cafaggi, S.

AU - Romussi, G.

PY - 1993

Y1 - 1993

N2 - A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy

AB - A method for the detection and quantitation of several undeclared drugs in herbal preparations with slimming activity is proposed. Samples containing various anorexics, hypoglycemics and antidepressants were prepared by addition of the drugs to a synthetic mixture containing the most commonly used plant powders for those preparations. Each sample was subjected to a treatment that permitted, after a simple ethanolic extraction, the identification of the drugs by TLC using three different solvent systems. A further purification of the ethanolic solution through a polyamide column allowed for quantitative analysis of the drugs by a RP-HPLC method. The analytical recovery was good (88-97%); the calibration curves were linear over a wide range of drug concentrations (30-500 μg/ml) (r > 0.9995); the precision was high (CV% = 0.4-2.8) as well as the accuracy

UR - http://www.scopus.com/inward/record.url?scp=0027454231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027454231&partnerID=8YFLogxK

M3 - Article

VL - 48

SP - 678

EP - 681

JO - Die Pharmazie

JF - Die Pharmazie

SN - 0031-7144

IS - 9

ER -