Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury

N. K. Hase, A. M. Iqbal, T. E. Jamale, M. Kulkarni, M. G. Kulkarni, K. J. Pradeep, E. Rurali, P. Shetty

Research output: Contribution to journalArticlepeer-review


We report here a case of 26-year-old male who presented with history of recurrent acute renal failure associated with microangiopathic hemolytic anemia and thrombocytopenia. ADAMTS 13 deficiency due to mutation in the gene encoding for ADAMTS 13 was identified as the cause. After eight episodes of acute kidney injury (AKI), patient started developing hypertension, proteinuria, and renal insufficiency. Treatment with regular monthly plasma infusions prevented further episodes of AKI and stabilized the renal function. Hypertension and proteinuria are controlled with angiotensin II receptor blockers.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalIndian Journal of Nephrology
Issue number4
Publication statusPublished - Jul 2012


  • ADAMTS 13 deficiency
  • chronic kidney disease
  • plasma therapy
  • proteinuria
  • recurrent acute kidney injury

ASJC Scopus subject areas

  • Nephrology


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