Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury

N. K. Hase, A. M. Iqbal, T. E. Jamale, M. Kulkarni, M. G. Kulkarni, K. J. Pradeep, E. Rurali, P. Shetty

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report here a case of 26-year-old male who presented with history of recurrent acute renal failure associated with microangiopathic hemolytic anemia and thrombocytopenia. ADAMTS 13 deficiency due to mutation in the gene encoding for ADAMTS 13 was identified as the cause. After eight episodes of acute kidney injury (AKI), patient started developing hypertension, proteinuria, and renal insufficiency. Treatment with regular monthly plasma infusions prevented further episodes of AKI and stabilized the renal function. Hypertension and proteinuria are controlled with angiotensin II receptor blockers.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalIndian Journal of Nephrology
Volume22
Issue number4
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Acute Kidney Injury
Proteinuria
Hypertension
Angiotensin Receptor Antagonists
Hemolytic Anemia
Thrombocytopenia
Renal Insufficiency
Kidney
Mutation
Genes
Therapeutics

Keywords

  • ADAMTS 13 deficiency
  • chronic kidney disease
  • plasma therapy
  • proteinuria
  • recurrent acute kidney injury

ASJC Scopus subject areas

  • Nephrology

Cite this

Hase, N. K., Iqbal, A. M., Jamale, T. E., Kulkarni, M., Kulkarni, M. G., Pradeep, K. J., ... Shetty, P. (2012). Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury. Indian Journal of Nephrology, 22(4), 298-300. https://doi.org/10.4103/0971-4065.101257

Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury. / Hase, N. K.; Iqbal, A. M.; Jamale, T. E.; Kulkarni, M.; Kulkarni, M. G.; Pradeep, K. J.; Rurali, E.; Shetty, P.

In: Indian Journal of Nephrology, Vol. 22, No. 4, 07.2012, p. 298-300.

Research output: Contribution to journalArticle

Hase, NK, Iqbal, AM, Jamale, TE, Kulkarni, M, Kulkarni, MG, Pradeep, KJ, Rurali, E & Shetty, P 2012, 'Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury', Indian Journal of Nephrology, vol. 22, no. 4, pp. 298-300. https://doi.org/10.4103/0971-4065.101257
Hase NK, Iqbal AM, Jamale TE, Kulkarni M, Kulkarni MG, Pradeep KJ et al. Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury. Indian Journal of Nephrology. 2012 Jul;22(4):298-300. https://doi.org/10.4103/0971-4065.101257
Hase, N. K. ; Iqbal, A. M. ; Jamale, T. E. ; Kulkarni, M. ; Kulkarni, M. G. ; Pradeep, K. J. ; Rurali, E. ; Shetty, P. / Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury. In: Indian Journal of Nephrology. 2012 ; Vol. 22, No. 4. pp. 298-300.
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