Hereditary angioedema: An appraisal of 104 cases

M. Cicardi, L. Bergamaschini, B. Marasini, G. Boccassini, A. Tucci, A. Agostoni

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Abstract

One hundred and four patients affected by hereditary angioedema belonging to 31 families have been studied. Twenty-two percent had the variant form related to the deficiency of the functional activity of serum C1 esterase inhibitor. The remaining 78% of patients had the predominant form, characterized by low antigenic levels and low functional activity of serum C1 esterase inhibitor. Attacks of swelling affected the subcutaneous tissue in 86% of patients; the upper airways in 76% of patients, and the bowel mucosa in 75% of patients. Before treatment was available the mortality rate was 56%. One or more attacks a month were present in 46% of cases. The infusion of C1 inhibitor concentrate promptly reversed 14 severe attacks without any side effect. Twenty-nine patients were given a long term prophylactic treatment with androgen derivatives with full success. Tranexamic acid reduced the frequency of swelling of 70% of the patients.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalAmerican Journal of the Medical Sciences
Volume284
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Medicine(all)

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    Cicardi, M., Bergamaschini, L., Marasini, B., Boccassini, G., Tucci, A., & Agostoni, A. (1982). Hereditary angioedema: An appraisal of 104 cases. American Journal of the Medical Sciences, 284(1), 2-9.