Hereditary deficiency of gp91phox is associated with enhanced arterial dilatation: Results of a multicenter study

Francesco Violi, Valerio Sanguigni, Roberto Carnevale, Alessandro Plebani, Paolo Rossi, Andrea Finocchi, Claudio Pignata, Domenico De Mattia, Baldassarre Martire, Maria Cristina Pietrogrande, Silvana Martino, Eleonora Gambineri, Anna Rosa Soresina, Pasquale Pignatelli, Francesco Martino, Stefania Basili, Lorenzo Loffredo

Research output: Contribution to journalArticle

Abstract

BACKGROUND-: NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unclear. The objective of this study was to evaluate whether NADPH oxidase is involved in flow-mediated arterial dilation (FMD). METHODS AND RESULTS-: Twenty-five patients with hereditary deficiency of gp91, the catalytic core of NADPH oxidase, (X-CGD), 25 healthy subjects, and 25 obese patients matched for sex and age were recruited. FMD, platelet gp91, serum levels of nitrite and nitrate as markers of nitric oxide generation, oxidized low-density lipoprotein, and urinary excretion of isoprostanes as markers of oxidative stress were determined. Platelet gp91 expression was downregulated in X-CGD patients (1.0±0.8 mean fluorescence; P

Original languageEnglish
Pages (from-to)1616-1622
Number of pages7
JournalCirculation
Volume120
Issue number16
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Atherosclerosis
  • Gp91phox protein
  • Human
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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    Violi, F., Sanguigni, V., Carnevale, R., Plebani, A., Rossi, P., Finocchi, A., Pignata, C., De Mattia, D., Martire, B., Pietrogrande, M. C., Martino, S., Gambineri, E., Soresina, A. R., Pignatelli, P., Martino, F., Basili, S., & Loffredo, L. (2009). Hereditary deficiency of gp91phox is associated with enhanced arterial dilatation: Results of a multicenter study. Circulation, 120(16), 1616-1622. https://doi.org/10.1161/CIRCULATIONAHA.109.877191