Hereditary Fructose Intolerance and Celiac Disease: A Novel Genetic Association

Carolina Ciacci, Daniela Gennarelli, Gabriella Esposito, Raffaella Tortora, Francesco Salvatore, Lucia Sacchetti

Research output: Contribution to journalArticle

Abstract

Background & Aims: Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI). Methods: We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients. Results: Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%-3%) (P <.02). Conclusions: The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.

Original languageEnglish
Pages (from-to)635-638
Number of pages4
JournalClinical Gastroenterology and Hepatology
Volume4
Issue number5
DOIs
Publication statusPublished - May 2006

ASJC Scopus subject areas

  • Gastroenterology

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    Ciacci, C., Gennarelli, D., Esposito, G., Tortora, R., Salvatore, F., & Sacchetti, L. (2006). Hereditary Fructose Intolerance and Celiac Disease: A Novel Genetic Association. Clinical Gastroenterology and Hepatology, 4(5), 635-638. https://doi.org/10.1016/j.cgh.2005.12.004