Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?

Mauro Bozzola, Chiara Gertosio, Maria Gnoli, Federico Baronio, Elena Pedrini, Cristina Meazza, Luca Sangiorgi

Research output: Contribution to journalArticle

Abstract

BACKGROUND:
Osteochondroma generally occurs as a single lesion and it is not a heritable disease. When two or more osteochondroma are present, this condition represents a genetic disorder named hereditary multiple exostoses (HME). Growth hormone deficiency (GHD) has rarely been found in HME patients and a few data about growth therapy (GH) therapy effects in development/growth of solitary or multiple exostoses have been reported.
CASE PRESENTATION:
We describe the clinical features of 2 patients (one with osteochondroma and one with HME) evaluated before and after GH therapy. In the first patient, the single osteochondroma was noticed after the start of treatment; the other patient showed no evidence of significant increase in size or number of lesions related to GH therapy.
CONCLUSION:
It is necessary to investigate GH secretion in patients with osteochondroma or HME and short stature because they could benefit from GH replacement therapy. Moreover, careful clinical and imaging follow-up of exostoses is mandatory.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalItalian Journal of Pediatrics
Publication statusPublished - Aug 2015

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Multiple Hereditary Exostoses
Osteochondroma
Growth Hormone
Therapeutics
Growth
Exostoses
Inborn Genetic Diseases
Growth and Development

Cite this

Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat? / Bozzola, Mauro; Gertosio, Chiara; Gnoli, Maria; Baronio, Federico; Pedrini, Elena; Meazza, Cristina; Sangiorgi, Luca.

In: Italian Journal of Pediatrics, 08.2015, p. 1-6.

Research output: Contribution to journalArticle

Bozzola, Mauro ; Gertosio, Chiara ; Gnoli, Maria ; Baronio, Federico ; Pedrini, Elena ; Meazza, Cristina ; Sangiorgi, Luca. / Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?. In: Italian Journal of Pediatrics. 2015 ; pp. 1-6.
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AU - Bozzola, Mauro

AU - Gertosio, Chiara

AU - Gnoli, Maria

AU - Baronio, Federico

AU - Pedrini, Elena

AU - Meazza, Cristina

AU - Sangiorgi, Luca

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N2 - BACKGROUND:Osteochondroma generally occurs as a single lesion and it is not a heritable disease. When two or more osteochondroma are present, this condition represents a genetic disorder named hereditary multiple exostoses (HME). Growth hormone deficiency (GHD) has rarely been found in HME patients and a few data about growth therapy (GH) therapy effects in development/growth of solitary or multiple exostoses have been reported.CASE PRESENTATION:We describe the clinical features of 2 patients (one with osteochondroma and one with HME) evaluated before and after GH therapy. In the first patient, the single osteochondroma was noticed after the start of treatment; the other patient showed no evidence of significant increase in size or number of lesions related to GH therapy.CONCLUSION:It is necessary to investigate GH secretion in patients with osteochondroma or HME and short stature because they could benefit from GH replacement therapy. Moreover, careful clinical and imaging follow-up of exostoses is mandatory.

AB - BACKGROUND:Osteochondroma generally occurs as a single lesion and it is not a heritable disease. When two or more osteochondroma are present, this condition represents a genetic disorder named hereditary multiple exostoses (HME). Growth hormone deficiency (GHD) has rarely been found in HME patients and a few data about growth therapy (GH) therapy effects in development/growth of solitary or multiple exostoses have been reported.CASE PRESENTATION:We describe the clinical features of 2 patients (one with osteochondroma and one with HME) evaluated before and after GH therapy. In the first patient, the single osteochondroma was noticed after the start of treatment; the other patient showed no evidence of significant increase in size or number of lesions related to GH therapy.CONCLUSION:It is necessary to investigate GH secretion in patients with osteochondroma or HME and short stature because they could benefit from GH replacement therapy. Moreover, careful clinical and imaging follow-up of exostoses is mandatory.

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