Heritability of cerebral arterial velocity and resistance

Adam Domonkos Tarnoki, David Laszlo Tarnoki, Maria Fabrizia Giannoni, Claudio Baracchini, Giorgio Meneghetti, Gabriela Cardaioli, Emanuela Medda, Maria Antonietta Stazi, Rodolfo Cotichini, Corrado Fagnani, Lorenza Nisticò, Pierleone Lucatelli, Fabrizio Fanelli, Viktor Berczi, Zsolt Garami, Levente Littvay, Giuseppe Schillaci

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aims: Cerebrovascular resistance is a pressure-dependent mechanism resulting from cerebral autoregulation, which is the normal buffering of changes in arterial blood pressure. Lifestyle habits are known to have an influence; however, its magnitude is still unclear. The aimof this study was to assess the contribution of additive genetic, shared and unshared environmental factors to changes in middle cerebral artery (MCA) mean flow velocities (MFVs) and pulsatility index. Methods: One hundred and forty-three Italian twin pairs from Padua, Perugia and Rome (68 monozygotic, 75 dizygotic, 55 ± 12 years) underwent transcranial Doppler sonography of the MCA bilaterally. Univariate quantitative genetic modeling was performed to decompose the phenotypic variance of averaged MFV and pulsatility index into additive genetic, shared and unique environmental effects adjusted by age and sex. Results: MFV was heritable in 30.6%[95% confidence interval (CI) 0.8-67.3%], and shared and unshared environmental factors explained 47.7 and 21.6% of the variance (95% CI 14.4-71.9% and 12.6-32.0%). Pulsatility index was not genetically determined, but unique and common environmental factors were responsible for 54.2 and 38.1% of the variance (95% CI 36.3-71.8% and 0.0-57.8%). Conclusion: These findings underline the importance of identification of the specific genes and common environmental factors related to MFV. Individuals with positive family history of stroke related to the atherosclerosis of MCA might take advantage from preventive ultrasound screening. More emphasis should be placed on the prevention of the known related common environmental factors on MFV and the individual lifestyle risk factors on pulsatility index.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Middle Cerebral Artery
Confidence Intervals
Life Style
Doppler Transcranial Ultrasonography
Habits
Atherosclerosis
Arterial Pressure
Homeostasis
Stroke
Pressure
Genes

Keywords

  • Cerebral autoregulation
  • Cerebral hemodynamics
  • Genetics
  • Intracranial atherosclerosis
  • Transcranial doppler
  • Twin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tarnoki, A. D., Tarnoki, D. L., Giannoni, M. F., Baracchini, C., Meneghetti, G., Cardaioli, G., ... Schillaci, G. (2017). Heritability of cerebral arterial velocity and resistance. Journal of Cardiovascular Medicine, 18(1), 28-33. https://doi.org/10.2459/JCM.0000000000000230

Heritability of cerebral arterial velocity and resistance. / Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Giannoni, Maria Fabrizia; Baracchini, Claudio; Meneghetti, Giorgio; Cardaioli, Gabriela; Medda, Emanuela; Stazi, Maria Antonietta; Cotichini, Rodolfo; Fagnani, Corrado; Nisticò, Lorenza; Lucatelli, Pierleone; Fanelli, Fabrizio; Berczi, Viktor; Garami, Zsolt; Littvay, Levente; Schillaci, Giuseppe.

In: Journal of Cardiovascular Medicine, Vol. 18, No. 1, 01.01.2017, p. 28-33.

Research output: Contribution to journalArticle

Tarnoki, AD, Tarnoki, DL, Giannoni, MF, Baracchini, C, Meneghetti, G, Cardaioli, G, Medda, E, Stazi, MA, Cotichini, R, Fagnani, C, Nisticò, L, Lucatelli, P, Fanelli, F, Berczi, V, Garami, Z, Littvay, L & Schillaci, G 2017, 'Heritability of cerebral arterial velocity and resistance', Journal of Cardiovascular Medicine, vol. 18, no. 1, pp. 28-33. https://doi.org/10.2459/JCM.0000000000000230
Tarnoki AD, Tarnoki DL, Giannoni MF, Baracchini C, Meneghetti G, Cardaioli G et al. Heritability of cerebral arterial velocity and resistance. Journal of Cardiovascular Medicine. 2017 Jan 1;18(1):28-33. https://doi.org/10.2459/JCM.0000000000000230
Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Giannoni, Maria Fabrizia ; Baracchini, Claudio ; Meneghetti, Giorgio ; Cardaioli, Gabriela ; Medda, Emanuela ; Stazi, Maria Antonietta ; Cotichini, Rodolfo ; Fagnani, Corrado ; Nisticò, Lorenza ; Lucatelli, Pierleone ; Fanelli, Fabrizio ; Berczi, Viktor ; Garami, Zsolt ; Littvay, Levente ; Schillaci, Giuseppe. / Heritability of cerebral arterial velocity and resistance. In: Journal of Cardiovascular Medicine. 2017 ; Vol. 18, No. 1. pp. 28-33.
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AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Giannoni, Maria Fabrizia

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Cardaioli, Gabriela

AU - Medda, Emanuela

AU - Stazi, Maria Antonietta

AU - Cotichini, Rodolfo

AU - Fagnani, Corrado

AU - Nisticò, Lorenza

AU - Lucatelli, Pierleone

AU - Fanelli, Fabrizio

AU - Berczi, Viktor

AU - Garami, Zsolt

AU - Littvay, Levente

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N2 - Aims: Cerebrovascular resistance is a pressure-dependent mechanism resulting from cerebral autoregulation, which is the normal buffering of changes in arterial blood pressure. Lifestyle habits are known to have an influence; however, its magnitude is still unclear. The aimof this study was to assess the contribution of additive genetic, shared and unshared environmental factors to changes in middle cerebral artery (MCA) mean flow velocities (MFVs) and pulsatility index. Methods: One hundred and forty-three Italian twin pairs from Padua, Perugia and Rome (68 monozygotic, 75 dizygotic, 55 ± 12 years) underwent transcranial Doppler sonography of the MCA bilaterally. Univariate quantitative genetic modeling was performed to decompose the phenotypic variance of averaged MFV and pulsatility index into additive genetic, shared and unique environmental effects adjusted by age and sex. Results: MFV was heritable in 30.6%[95% confidence interval (CI) 0.8-67.3%], and shared and unshared environmental factors explained 47.7 and 21.6% of the variance (95% CI 14.4-71.9% and 12.6-32.0%). Pulsatility index was not genetically determined, but unique and common environmental factors were responsible for 54.2 and 38.1% of the variance (95% CI 36.3-71.8% and 0.0-57.8%). Conclusion: These findings underline the importance of identification of the specific genes and common environmental factors related to MFV. Individuals with positive family history of stroke related to the atherosclerosis of MCA might take advantage from preventive ultrasound screening. More emphasis should be placed on the prevention of the known related common environmental factors on MFV and the individual lifestyle risk factors on pulsatility index.

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