Heritability of cluster headache

Pasquale Montagna, Mirella Mochi, Guido Prologo, Simonetta Sangiorgi, Giulia Pierangeli, Sabina Cevoli, Pietro Cortelli

Research output: Contribution to journalArticle

Abstract

We conducted a pedigree analysis in 222 patients with cluster headaches (CHs) in order to assess a familial predisposition to the disease. Heritability was determined by Falconer's index (from the incidence of CH among first degree relatives of probands compared with a control population), which varies between 0 and 1 (none or full genetic causation). A positive family history (I/II degree relatives) was found in 2.3% of our CH patients. Three generations were affected in one family and two generations in another two families. The calculated Falconer's heritability index was, however, only 0.26 ± 0.25 SD. Our study confirms a higher familial occurrence of CH, some families showing a pattern compatible with autosomal dominant inheritance with reduced penetrance. The low Falconer's index indicates, however, a large non-genetic causation in most cases of CH.

Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalEuropean Journal of Neurology
Volume5
Issue number4
Publication statusPublished - 1998

Fingerprint

Cluster Headache
Causality
Penetrance
Pedigree
Incidence
Population

Keywords

  • Cluster headache
  • Familial
  • Genetic
  • Heritability

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Montagna, P., Mochi, M., Prologo, G., Sangiorgi, S., Pierangeli, G., Cevoli, S., & Cortelli, P. (1998). Heritability of cluster headache. European Journal of Neurology, 5(4), 343-345.

Heritability of cluster headache. / Montagna, Pasquale; Mochi, Mirella; Prologo, Guido; Sangiorgi, Simonetta; Pierangeli, Giulia; Cevoli, Sabina; Cortelli, Pietro.

In: European Journal of Neurology, Vol. 5, No. 4, 1998, p. 343-345.

Research output: Contribution to journalArticle

Montagna, P, Mochi, M, Prologo, G, Sangiorgi, S, Pierangeli, G, Cevoli, S & Cortelli, P 1998, 'Heritability of cluster headache', European Journal of Neurology, vol. 5, no. 4, pp. 343-345.
Montagna P, Mochi M, Prologo G, Sangiorgi S, Pierangeli G, Cevoli S et al. Heritability of cluster headache. European Journal of Neurology. 1998;5(4):343-345.
Montagna, Pasquale ; Mochi, Mirella ; Prologo, Guido ; Sangiorgi, Simonetta ; Pierangeli, Giulia ; Cevoli, Sabina ; Cortelli, Pietro. / Heritability of cluster headache. In: European Journal of Neurology. 1998 ; Vol. 5, No. 4. pp. 343-345.
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