Abstract
We conducted a pedigree analysis in 222 patients with cluster headaches (CHs) in order to assess a familial predisposition to the disease. Heritability was determined by Falconer's index (from the incidence of CH among first degree relatives of probands compared with a control population), which varies between 0 and 1 (none or full genetic causation). A positive family history (I/II degree relatives) was found in 2.3% of our CH patients. Three generations were affected in one family and two generations in another two families. The calculated Falconer's heritability index was, however, only 0.26 ± 0.25 SD. Our study confirms a higher familial occurrence of CH, some families showing a pattern compatible with autosomal dominant inheritance with reduced penetrance. The low Falconer's index indicates, however, a large non-genetic causation in most cases of CH.
| Original language | English |
|---|---|
| Pages (from-to) | 343-345 |
| Number of pages | 3 |
| Journal | European Journal of Neurology |
| Volume | 5 |
| Issue number | 4 |
| Publication status | Published - 1998 |
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Keywords
- Cluster headache
- Familial
- Genetic
- Heritability
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Heritability of cluster headache. / Montagna, Pasquale; Mochi, Mirella; Prologo, Guido; Sangiorgi, Simonetta; Pierangeli, Giulia; Cevoli, Sabina; Cortelli, Pietro.
In: European Journal of Neurology, Vol. 5, No. 4, 1998, p. 343-345.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heritability of cluster headache
AU - Montagna, Pasquale
AU - Mochi, Mirella
AU - Prologo, Guido
AU - Sangiorgi, Simonetta
AU - Pierangeli, Giulia
AU - Cevoli, Sabina
AU - Cortelli, Pietro
PY - 1998
Y1 - 1998
N2 - We conducted a pedigree analysis in 222 patients with cluster headaches (CHs) in order to assess a familial predisposition to the disease. Heritability was determined by Falconer's index (from the incidence of CH among first degree relatives of probands compared with a control population), which varies between 0 and 1 (none or full genetic causation). A positive family history (I/II degree relatives) was found in 2.3% of our CH patients. Three generations were affected in one family and two generations in another two families. The calculated Falconer's heritability index was, however, only 0.26 ± 0.25 SD. Our study confirms a higher familial occurrence of CH, some families showing a pattern compatible with autosomal dominant inheritance with reduced penetrance. The low Falconer's index indicates, however, a large non-genetic causation in most cases of CH.
AB - We conducted a pedigree analysis in 222 patients with cluster headaches (CHs) in order to assess a familial predisposition to the disease. Heritability was determined by Falconer's index (from the incidence of CH among first degree relatives of probands compared with a control population), which varies between 0 and 1 (none or full genetic causation). A positive family history (I/II degree relatives) was found in 2.3% of our CH patients. Three generations were affected in one family and two generations in another two families. The calculated Falconer's heritability index was, however, only 0.26 ± 0.25 SD. Our study confirms a higher familial occurrence of CH, some families showing a pattern compatible with autosomal dominant inheritance with reduced penetrance. The low Falconer's index indicates, however, a large non-genetic causation in most cases of CH.
KW - Cluster headache
KW - Familial
KW - Genetic
KW - Heritability
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UR - http://www.scopus.com/inward/citedby.url?scp=0031904513&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0031904513
VL - 5
SP - 343
EP - 345
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 4
ER -