Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

Adam Domonkos Tarnoki, Andrea Agnes Molnar, David Laszlo Tarnoki, Levente Littvay, Emanuela Medda, Corrado Fagnani, Antonio Arnolfi, Filippo Farina, Claudio Baracchini, Giorgio Meneghetti, Giacomo Pucci, Giuseppe Schillaci, Maria Antonietta Stazi, György L. Nadasy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims The elasticity of the internal jugular vein (IJV) is a major determinant of cerebral venous drainage and right atrium venous return. However, the level of genetic determination of IJV dimensions, compliance and distensibility has not been studied yet. Methods 170 adult Caucasian twins (43 monozygotic [MZ] and 42 dizygotic [DZ] pairs) were involved from the Italian twin registry. Anteroposterior and mediolateral diameters of the IJV were measured bilaterally by ultrasonography. Measurements were made both in the sitting and supine positions, with or without Valsalva maneuver. Univariate quantitative genetic modeling was performed. Results Genetic factors are responsible for 30–70% of the measured properties of IJV at higher venous pressure even after adjustment for age and gender. The highest level of inheritance was found in the supine position regarding compliance (62%) and venous diameter during Valsalva (69%). Environmental and measurement-related factors instead are more important in the sitting position, when the venous pressure is low and the venous lumen is almost collapsed. The range of capacity changes between the lowest and highest intraluminal venous pressure (full distension range) are mainly determined by genetic factors (58%). Conclusions Our study has shown substantial heritability of IJV biomechanics at higher venous pressures even after adjustment for age and gender. These findings yield an important insight to what degree the geometric and elastic properties of the vascular wall are formed by genetic and by environmental factors in humans.

Original languageEnglish
Article numbere0192948
JournalPLoS One
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Jugular Veins
jugular vein
Venous Pressure
compliance
Compliance
heritability
Supine Position
Posture
Ultrasonography
Biomechanics
Valsalva Maneuver
Monozygotic Twins
gender
Drainage
Elasticity
quantitative genetics
elasticity (mechanics)
Heart Atria
Biomechanical Phenomena
blood vessels

Keywords

  • heritability, jugular vein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall. / Tarnoki, Adam Domonkos; Molnar, Andrea Agnes; Tarnoki, David Laszlo; Littvay, Levente; Medda, Emanuela; Fagnani, Corrado; Arnolfi, Antonio; Farina, Filippo; Baracchini, Claudio; Meneghetti, Giorgio; Pucci, Giacomo; Schillaci, Giuseppe; Stazi, Maria Antonietta; Nadasy, György L.

In: PLoS One, Vol. 13, No. 3, e0192948, 01.03.2018.

Research output: Contribution to journalArticle

Tarnoki, AD, Molnar, AA, Tarnoki, DL, Littvay, L, Medda, E, Fagnani, C, Arnolfi, A, Farina, F, Baracchini, C, Meneghetti, G, Pucci, G, Schillaci, G, Stazi, MA & Nadasy, GL 2018, 'Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall', PLoS One, vol. 13, no. 3, e0192948. https://doi.org/10.1371/journal.pone.0192948
Tarnoki, Adam Domonkos ; Molnar, Andrea Agnes ; Tarnoki, David Laszlo ; Littvay, Levente ; Medda, Emanuela ; Fagnani, Corrado ; Arnolfi, Antonio ; Farina, Filippo ; Baracchini, Claudio ; Meneghetti, Giorgio ; Pucci, Giacomo ; Schillaci, Giuseppe ; Stazi, Maria Antonietta ; Nadasy, György L. / Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall. In: PLoS One. 2018 ; Vol. 13, No. 3.
@article{14a5a62f600d4da7bf6ddc3cfbcfb210,
title = "Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall",
abstract = "Aims The elasticity of the internal jugular vein (IJV) is a major determinant of cerebral venous drainage and right atrium venous return. However, the level of genetic determination of IJV dimensions, compliance and distensibility has not been studied yet. Methods 170 adult Caucasian twins (43 monozygotic [MZ] and 42 dizygotic [DZ] pairs) were involved from the Italian twin registry. Anteroposterior and mediolateral diameters of the IJV were measured bilaterally by ultrasonography. Measurements were made both in the sitting and supine positions, with or without Valsalva maneuver. Univariate quantitative genetic modeling was performed. Results Genetic factors are responsible for 30–70{\%} of the measured properties of IJV at higher venous pressure even after adjustment for age and gender. The highest level of inheritance was found in the supine position regarding compliance (62{\%}) and venous diameter during Valsalva (69{\%}). Environmental and measurement-related factors instead are more important in the sitting position, when the venous pressure is low and the venous lumen is almost collapsed. The range of capacity changes between the lowest and highest intraluminal venous pressure (full distension range) are mainly determined by genetic factors (58{\%}). Conclusions Our study has shown substantial heritability of IJV biomechanics at higher venous pressures even after adjustment for age and gender. These findings yield an important insight to what degree the geometric and elastic properties of the vascular wall are formed by genetic and by environmental factors in humans.",
keywords = "heritability, jugular vein",
author = "Tarnoki, {Adam Domonkos} and Molnar, {Andrea Agnes} and Tarnoki, {David Laszlo} and Levente Littvay and Emanuela Medda and Corrado Fagnani and Antonio Arnolfi and Filippo Farina and Claudio Baracchini and Giorgio Meneghetti and Giacomo Pucci and Giuseppe Schillaci and Stazi, {Maria Antonietta} and Nadasy, {Gy{\"o}rgy L.}",
year = "2018",
month = "3",
day = "1",
doi = "10.1371/journal.pone.0192948",
language = "English",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

AU - Tarnoki, Adam Domonkos

AU - Molnar, Andrea Agnes

AU - Tarnoki, David Laszlo

AU - Littvay, Levente

AU - Medda, Emanuela

AU - Fagnani, Corrado

AU - Arnolfi, Antonio

AU - Farina, Filippo

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Pucci, Giacomo

AU - Schillaci, Giuseppe

AU - Stazi, Maria Antonietta

AU - Nadasy, György L.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Aims The elasticity of the internal jugular vein (IJV) is a major determinant of cerebral venous drainage and right atrium venous return. However, the level of genetic determination of IJV dimensions, compliance and distensibility has not been studied yet. Methods 170 adult Caucasian twins (43 monozygotic [MZ] and 42 dizygotic [DZ] pairs) were involved from the Italian twin registry. Anteroposterior and mediolateral diameters of the IJV were measured bilaterally by ultrasonography. Measurements were made both in the sitting and supine positions, with or without Valsalva maneuver. Univariate quantitative genetic modeling was performed. Results Genetic factors are responsible for 30–70% of the measured properties of IJV at higher venous pressure even after adjustment for age and gender. The highest level of inheritance was found in the supine position regarding compliance (62%) and venous diameter during Valsalva (69%). Environmental and measurement-related factors instead are more important in the sitting position, when the venous pressure is low and the venous lumen is almost collapsed. The range of capacity changes between the lowest and highest intraluminal venous pressure (full distension range) are mainly determined by genetic factors (58%). Conclusions Our study has shown substantial heritability of IJV biomechanics at higher venous pressures even after adjustment for age and gender. These findings yield an important insight to what degree the geometric and elastic properties of the vascular wall are formed by genetic and by environmental factors in humans.

AB - Aims The elasticity of the internal jugular vein (IJV) is a major determinant of cerebral venous drainage and right atrium venous return. However, the level of genetic determination of IJV dimensions, compliance and distensibility has not been studied yet. Methods 170 adult Caucasian twins (43 monozygotic [MZ] and 42 dizygotic [DZ] pairs) were involved from the Italian twin registry. Anteroposterior and mediolateral diameters of the IJV were measured bilaterally by ultrasonography. Measurements were made both in the sitting and supine positions, with or without Valsalva maneuver. Univariate quantitative genetic modeling was performed. Results Genetic factors are responsible for 30–70% of the measured properties of IJV at higher venous pressure even after adjustment for age and gender. The highest level of inheritance was found in the supine position regarding compliance (62%) and venous diameter during Valsalva (69%). Environmental and measurement-related factors instead are more important in the sitting position, when the venous pressure is low and the venous lumen is almost collapsed. The range of capacity changes between the lowest and highest intraluminal venous pressure (full distension range) are mainly determined by genetic factors (58%). Conclusions Our study has shown substantial heritability of IJV biomechanics at higher venous pressures even after adjustment for age and gender. These findings yield an important insight to what degree the geometric and elastic properties of the vascular wall are formed by genetic and by environmental factors in humans.

KW - heritability, jugular vein

UR - http://www.scopus.com/inward/record.url?scp=85044331436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044331436&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0192948

DO - 10.1371/journal.pone.0192948

M3 - Article

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e0192948

ER -