Heritability of the femoral intima media thickness

Bence Fejer, Adam D. Tarnoki, David L. Tarnoki, Pierleone Lucatelli, Levente Littvay, Pal Maurovich-Horvat, Adam L. Jermendy, Attila Kovacs, Erika Godor, Corrado Fagnani, Maria A. Stazi, Andrea A. Molnar, Fabrizio Fanelli, Carlo Cirelli, Filippo Farina, Claudio Baracchini, Giorgio Meneghetti, Giacomo Pucci, Gyorgy Jermendy, Bela MerkelyGiuseppe Schillaci, Emanuela Medda

Research output: Contribution to journalArticle

Abstract

Background The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. Materials and methods 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers. Results Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%–65.2%) and 47.2% (95% CI, 31.4%–62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%–78.5%) and 52.8% (95% CI, 37.2%–68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure. Conclusions Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

Original languageEnglish
Pages (from-to)44-48
Number of pages5
JournalEuropean Journal of Internal Medicine
Volume41
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Atherosclerosis
  • Cardiovascular risk
  • Circulation
  • Gene
  • Twins

ASJC Scopus subject areas

  • Internal Medicine

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    Fejer, B., Tarnoki, A. D., Tarnoki, D. L., Lucatelli, P., Littvay, L., Maurovich-Horvat, P., Jermendy, A. L., Kovacs, A., Godor, E., Fagnani, C., Stazi, M. A., Molnar, A. A., Fanelli, F., Cirelli, C., Farina, F., Baracchini, C., Meneghetti, G., Pucci, G., Jermendy, G., ... Medda, E. (2017). Heritability of the femoral intima media thickness. European Journal of Internal Medicine, 41, 44-48. https://doi.org/10.1016/j.ejim.2017.02.019