Heritable arrhythmias associated with abnormal function of cardiac potassium channels

Lia Crotti, Katja E. Odening, Michael C. Sanguinetti

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentrations of intracellular sodium, calcium, and ATP/ADP. Here, we review the diversity and functional roles of cardiac potassium channels under normal conditions and how heritable mutations in the genes encoding these channels can lead to distinct arrhythmias. We briefly review atrial fibrillation and J-wave syndromes. For long and short QT syndromes, we describe their genetic basis, clinical manifestation, risk stratification, traditional and novel therapeutic approaches, as well as insights into disease mechanisms provided by animal and cellular models.

Original languageEnglish
Pages (from-to)1542-1556
Number of pages15
JournalCardiovascular Research
Volume116
Issue number9
DOIs
Publication statusPublished - Jul 15 2020

Keywords

  • Long QT syndrome Short QT syndrome Potassium channels Atrial fibrillation Sudden cardiac death

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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