Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Loredana D'Este, Alessandra Scontrini, Arianna Casini, Francesco E. Pontieri, Tindaro G. Renda

Research output: Contribution to journalArticle

Abstract

Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalBrain Research
Volume933
Issue number2
DOIs
Publication statusPublished - Apr 19 2002

Fingerprint

Heroin
Proto-Oncogene Proteins c-fos
Pharmaceutical Preparations
Putamen
Nucleus Accumbens
Prosencephalon
History
Immunohistochemistry
Injections

Keywords

  • c-Fos oncoprotein
  • Caudate-putamen
  • Heroin
  • Immunohistochemistry
  • Nucleus accumbens shell
  • Sensitization

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum. / D'Este, Loredana; Scontrini, Alessandra; Casini, Arianna; Pontieri, Francesco E.; Renda, Tindaro G.

In: Brain Research, Vol. 933, No. 2, 19.04.2002, p. 144-149.

Research output: Contribution to journalArticle

D'Este, Loredana ; Scontrini, Alessandra ; Casini, Arianna ; Pontieri, Francesco E. ; Renda, Tindaro G. / Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum. In: Brain Research. 2002 ; Vol. 933, No. 2. pp. 144-149.
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