Abstract
Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.
| Original language | English |
|---|---|
| Pages (from-to) | 144-149 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 933 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 19 2002 |
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Keywords
- c-Fos oncoprotein
- Caudate-putamen
- Heroin
- Immunohistochemistry
- Nucleus accumbens shell
- Sensitization
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum. / D'Este, Loredana; Scontrini, Alessandra; Casini, Arianna; Pontieri, Francesco E.; Renda, Tindaro G.
In: Brain Research, Vol. 933, No. 2, 19.04.2002, p. 144-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum
AU - D'Este, Loredana
AU - Scontrini, Alessandra
AU - Casini, Arianna
AU - Pontieri, Francesco E.
AU - Renda, Tindaro G.
PY - 2002/4/19
Y1 - 2002/4/19
N2 - Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.
AB - Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.
KW - c-Fos oncoprotein
KW - Caudate-putamen
KW - Heroin
KW - Immunohistochemistry
KW - Nucleus accumbens shell
KW - Sensitization
UR - http://www.scopus.com/inward/record.url?scp=0037134180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037134180&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(02)02312-0
DO - 10.1016/S0006-8993(02)02312-0
M3 - Article
C2 - 11931859
AN - SCOPUS:0037134180
VL - 933
SP - 144
EP - 149
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -