Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Loredana D'Este; Alessandra Scontrini; Arianna Casini; Francesco E. Pontieri; Tindaro G. Renda

doi:10.1016/S0006-8993(02)02312-0

Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Loredana D'Este, Alessandra Scontrini, Arianna Casini, Francesco E. Pontieri, Tindaro G. Renda

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

Original language	English
Pages (from-to)	144-149
Number of pages	6
Journal	Brain Research
Volume	933
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(02)02312-0
Publication status	Published - Apr 19 2002

Keywords

c-Fos oncoprotein
Caudate-putamen
Heroin
Immunohistochemistry
Nucleus accumbens shell
Sensitization

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0006-8993(02)02312-0

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title = "Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum",

abstract = "Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.",

keywords = "c-Fos oncoprotein, Caudate-putamen, Heroin, Immunohistochemistry, Nucleus accumbens shell, Sensitization",

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AU - D'Este, Loredana

AU - Scontrini, Alessandra

AU - Casini, Arianna

AU - Pontieri, Francesco E.

AU - Renda, Tindaro G.

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AB - Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

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KW - Caudate-putamen

KW - Heroin

KW - Immunohistochemistry

KW - Nucleus accumbens shell

KW - Sensitization

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