Abstract
Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.
Original language | English |
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Pages (from-to) | 144-149 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 933 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 19 2002 |
Keywords
- c-Fos oncoprotein
- Caudate-putamen
- Heroin
- Immunohistochemistry
- Nucleus accumbens shell
- Sensitization
ASJC Scopus subject areas
- Neuroscience(all)