Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Loredana D'Este, Alessandra Scontrini, Arianna Casini, Francesco E. Pontieri, Tindaro G. Renda

Research output: Contribution to journalArticlepeer-review

Abstract

Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalBrain Research
Volume933
Issue number2
DOIs
Publication statusPublished - Apr 19 2002

Keywords

  • c-Fos oncoprotein
  • Caudate-putamen
  • Heroin
  • Immunohistochemistry
  • Nucleus accumbens shell
  • Sensitization

ASJC Scopus subject areas

  • Neuroscience(all)

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