Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Loredana D'Este; Alessandra Scontrini; Arianna Casini; Francesco E. Pontieri; Tindaro G. Renda

doi:10.1016/S0006-8993(02)02312-0

Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Loredana D'Este, Alessandra Scontrini, Arianna Casini, Francesco E. Pontieri, Tindaro G. Renda

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

Original language	English
Pages (from-to)	144-149
Number of pages	6
Journal	Brain Research
Volume	933
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(02)02312-0
Publication status	Published - Apr 19 2002

Keywords

c-Fos oncoprotein
Caudate-putamen
Heroin
Immunohistochemistry
Nucleus accumbens shell
Sensitization

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/S0006-8993(02)02312-0

Cite this

@article{5ce2740ed2254a0b839b20bdfbfc0e65,

title = "Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum",

abstract = "Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.",

keywords = "c-Fos oncoprotein, Caudate-putamen, Heroin, Immunohistochemistry, Nucleus accumbens shell, Sensitization",

author = "Loredana D'Este and Alessandra Scontrini and Arianna Casini and Pontieri, {Francesco E.} and Renda, {Tindaro G.}",

year = "2002",

month = apr,

day = "19",

doi = "10.1016/S0006-8993(02)02312-0",

language = "English",

volume = "933",

pages = "144--149",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

AU - D'Este, Loredana

AU - Scontrini, Alessandra

AU - Casini, Arianna

AU - Pontieri, Francesco E.

AU - Renda, Tindaro G.

PY - 2002/4/19

Y1 - 2002/4/19

N2 - Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

AB - Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

KW - c-Fos oncoprotein

KW - Caudate-putamen

KW - Heroin

KW - Immunohistochemistry

KW - Nucleus accumbens shell

KW - Sensitization

UR - http://www.scopus.com/inward/record.url?scp=0037134180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037134180&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(02)02312-0

DO - 10.1016/S0006-8993(02)02312-0

M3 - Article

C2 - 11931859

AN - SCOPUS:0037134180

VL - 933

SP - 144

EP - 149

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this