Herpes infections in breast cancer patients treated with adjuvant chemotherapy

Giovanna Masci, Massimo Magagnoli, Giuseppe Gullo, Emanuela Morenghi, Isabella Garassino, Matteo Simonelli, Armando Santoro

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: There is little information on Herpes zoster infection in breast cancer patients as a complication during adjuvant chemotherapy. The aim of this study is to evaluate the incidence of Herpes zoster and simplex infections in this patients setting. Methods: We analyzed 623 early-stage breast cancer patients in our Institute over a period of 7 years (1998-2005). Four-hundred and sixty-onepatients were treated with anthracycline-based chemotherapy, 116 with CMF and 46 with taxane-containing regimens. Results: Twelve (1.9%) developed herpes zoster; 9 patients, receiving anthracycline-based chemotherapy, two taxane-containing regimens, and one CMF regimen. Herpes zoster infection required treatment delay in 6 patients. Adjuvant chemotherapy was delayed for 1 week in 2 patients, while in 4 patients with more severe symptoms chemotherapy was delayed for 2 weeks. One patient, despite i.v. acyclovir, had severe postherpetic motor neuropathy with a permanent ambulation impairment, and chemotherapy was stopped. In our study, herpes zoster occurred in 55/1,000 cases/year. The reported incidence in the general population varies between 2.2 and 4.1 per 1,000 patients/year; therefore, the risk of developing herpes zoster in these patients may be 13- to 25-fold higher compared to the incidence in the general population. In addition, 13 of 623 patients developed herpes simplex. Conclusion: Our findings suggest that adjuvant chemotherapy can facilitate reactivation of herpes infection.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalOncology
Volume71
Issue number3-4
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Adjuvant chemotherapy
  • Breast cancer
  • Herpes infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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