Herpes simplex encephalitis in glioma patients: A challenging diagnosis

Giulia Berzero, Anna Luisa Di Stefano, Caroline Dehais, Marc Sanson, Paola Gaviani, Antonio Silvani, Andrea Salmaggi, Paolo Vitali, Luca Diamanti, Fausto Baldanti, Lisa Maria Farina, Mauro Ceroni, Enrico Marchioni

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: In recent years, herpes simplex encephalitis (HSE) has been reported with increasing frequency in settings of immunosuppression, such as acquired immunodeficiency, transplantation and cancer. As observed, in immunocompromised individuals HSE presents peculiar clinical and paraclinical features, and poorer prognosis. Methods: Here we describe a retrospective series of seven cases of HSE in patients with high-grade glioma (HGG), collected among three institutions in a 5-year period (during this time, a total of 1750 patients with HGG were treated). Results: Diagnosis of the condition was particularly challenging due to the confounding clinical presentation and the atypical biological findings. As a result, antiviral treatment was started with a sharp delay compared with immunocompetent hosts. Prognosis was poor, with high short-term mortality and severe residual disability in survivors. Conclusions: The substantial incidence of HSE observed in our centres together with the difficulty in diagnosing the condition suggest that the incidence of this complication may be highly underestimated. The aim of our report is to strengthen the observation of HSE in patients with HGG and outline the key elements that may allow its diagnosis.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Herpes Simplex Encephalitis
Glioma
Incidence
Immunosuppression
Antiviral Agents
Survivors
Transplantation
Observation
Mortality
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

Cite this

Herpes simplex encephalitis in glioma patients : A challenging diagnosis. / Berzero, Giulia; Stefano, Anna Luisa Di; Dehais, Caroline; Sanson, Marc; Gaviani, Paola; Silvani, Antonio; Salmaggi, Andrea; Vitali, Paolo; Diamanti, Luca; Baldanti, Fausto; Farina, Lisa Maria; Ceroni, Mauro; Marchioni, Enrico.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 86, No. 4, 01.04.2015, p. 374-377.

Research output: Contribution to journalArticle

Berzero, Giulia ; Stefano, Anna Luisa Di ; Dehais, Caroline ; Sanson, Marc ; Gaviani, Paola ; Silvani, Antonio ; Salmaggi, Andrea ; Vitali, Paolo ; Diamanti, Luca ; Baldanti, Fausto ; Farina, Lisa Maria ; Ceroni, Mauro ; Marchioni, Enrico. / Herpes simplex encephalitis in glioma patients : A challenging diagnosis. In: Journal of Neurology, Neurosurgery and Psychiatry. 2015 ; Vol. 86, No. 4. pp. 374-377.
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AU - Silvani, Antonio

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AU - Ceroni, Mauro

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