Herpes simplex virus and human cancer. III. Search for relationship of herpes simplex antibodies and cervical dysplasia and labial neoplasia.

A. Rotola, G. Gerna, D. Di Luca, A. R. Virgili, R. Manservigi, E. Cassai

Research output: Contribution to journalArticle

Abstract

We employed the enzyme-linked immunosorbent assay (ELISA), indirect hemagglutination (IHA), and complement fixation (CF) methods to measure antibody titer to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in patients affected by labial tumors or cervical dysplasias. No relationship of antibody titer to HSV-1 and labial tumors was detected by any of the three methods. Association between antibody titer to HSV-2 and cervical dysplasias was revealed by IHA (p less than 0.05) and ELISA (p less than 0.001); CF tests were negative. Moreover, we assayed for HSV-specific antigens in cell cultures derived from labial tumors and cervical dysplasias. In cultures from labial tumors, it was not possible to detect HSV-specific antigens. Of the 25 cultures derived from cervical dysplasias, HSV antigens were found in only 3 cultures.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalTumori
Volume69
Issue number2
Publication statusPublished - Apr 30 1983

ASJC Scopus subject areas

  • Cancer Research

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