Abstract
Introduction: Alzheimer’s disease (AD), the most common form of dementia worldwide, is a multifactorial disease with a still unknown etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to be one of the factors involved in the pathogenesis of the disease. Areas covered: We review the literature focusing on viral characteristics of HSV-1, the mechanisms this virus uses to infect neural cells, its interaction with the host immune system and genetic background and summarizes results and research that support the hypothesis of an association between AD and HSV-1. The possible usefulness of virus-directed pharmaceutical approaches as potential treatments for AD will be discussed as well. Expert opinion: We highlight crucial aspects that must be addressed to clarify the possible role of HSV-1 in the pathogenesis of the disease, and to allow the design of new therapeutical approaches for AD.
| Original language | English |
|---|---|
| Journal | Expert Review of Anti-Infective Therapy |
| DOIs | |
| Publication status | Published - Aug 1 2019 |
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Keywords
- Alzheimer’s disease
- human herpes simplex virus type-I
- immunity
- mild cognitive impairment
- pharmaceutical treatments
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
- Infectious Diseases
- Virology
Cite this
Herpes simplex virus type 1 and Alzheimer’s disease : link and potential impact on treatment. / Mancuso, Roberta; Sicurella, Mariaconcetta; Agostini, Simone; Marconi, Peggy; Clerici, Mario.
In: Expert Review of Anti-Infective Therapy, 01.08.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Herpes simplex virus type 1 and Alzheimer’s disease
T2 - link and potential impact on treatment
AU - Mancuso, Roberta
AU - Sicurella, Mariaconcetta
AU - Agostini, Simone
AU - Marconi, Peggy
AU - Clerici, Mario
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Introduction: Alzheimer’s disease (AD), the most common form of dementia worldwide, is a multifactorial disease with a still unknown etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to be one of the factors involved in the pathogenesis of the disease. Areas covered: We review the literature focusing on viral characteristics of HSV-1, the mechanisms this virus uses to infect neural cells, its interaction with the host immune system and genetic background and summarizes results and research that support the hypothesis of an association between AD and HSV-1. The possible usefulness of virus-directed pharmaceutical approaches as potential treatments for AD will be discussed as well. Expert opinion: We highlight crucial aspects that must be addressed to clarify the possible role of HSV-1 in the pathogenesis of the disease, and to allow the design of new therapeutical approaches for AD.
AB - Introduction: Alzheimer’s disease (AD), the most common form of dementia worldwide, is a multifactorial disease with a still unknown etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to be one of the factors involved in the pathogenesis of the disease. Areas covered: We review the literature focusing on viral characteristics of HSV-1, the mechanisms this virus uses to infect neural cells, its interaction with the host immune system and genetic background and summarizes results and research that support the hypothesis of an association between AD and HSV-1. The possible usefulness of virus-directed pharmaceutical approaches as potential treatments for AD will be discussed as well. Expert opinion: We highlight crucial aspects that must be addressed to clarify the possible role of HSV-1 in the pathogenesis of the disease, and to allow the design of new therapeutical approaches for AD.
KW - Alzheimer’s disease
KW - human herpes simplex virus type-I
KW - immunity
KW - mild cognitive impairment
KW - pharmaceutical treatments
UR - http://www.scopus.com/inward/record.url?scp=85070946215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070946215&partnerID=8YFLogxK
U2 - 10.1080/14787210.2019.1656064
DO - 10.1080/14787210.2019.1656064
M3 - Review article
AN - SCOPUS:85070946215
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
ER -