Herringbone-like hydrodynamic structures in microchannels: A CFD model to evaluate the enhancement of surface binding

Elena Bianchi, Monica Piergiovanni, Chiara Arrigoni, Junji Fukuda, Alfonso Gautieri, Matteo Moretti, Gabriele Dubini

Research output: Contribution to journalArticle

Abstract

Selected adsorption efficiency of a molecule in solution in a microchannel is strongly influenced by the convective/diffusive mass transport phenomena that supply the target molecule to the adsorption surface. In a standard microchannel with a rectangular cross section, laminar flow regime limits the fluid mixing, thus suggesting that mass transport conditions can be improved by the introduction of herringbone-like structures. Tuning of these geometrical patterns increases the concentration gradient of the target molecule at the adsorption surface. A computational fluid dynamic (CFD) study was performed to evaluate the relation between the geometrical herringbone patterns and the concentration gradient improvement in a 14 mm long microchannel. The results show that the inhomogeneity of the concentration gradient can provide an improved and localized adsorption under specific geometrical features, which can be tuned in order to adapt the adsorption pattern to the specific assay requirements.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalMedical Engineering and Physics
Volume48
DOIs
Publication statusPublished - Oct 1 2017

Keywords

  • Chaotic advection
  • Computational fluid dynamics
  • Lab on chip
  • Passive mixing

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering

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