Heterogeneity in ALSFRS-R decline and survival: a population-based study in Italy

Jessica Mandrioli, Sara Biguzzi, Carlo Guidi, Elisabetta Sette, Emilio Terlizzi, Alessandro Ravasio, Mario Casmiro, Fabrizio Salvi, Rocco Liguori, Romana Rizzi, Vladimiro Pietrini, Annamaria Borghi, Rita Rinaldi, Nicola Fini, Elisabetta Chierici, Mario Santangelo, Enrico Granieri, Vittoria Mussuto, Silvia De Pasqua, Eleni GeorgoulopoulouAntonio Fasano, Salvatore Ferro, Roberto D'Alessandro, ERRALS Group

Research output: Contribution to journalArticle

Abstract

Very few studies examined trend over time of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and factors influencing it; previous studies, then, included only patients attending tertiary ALS Centres. We studied ALSFRS-R decline, factors influencing this trend and survival in a population-based setting. From 2009 onwards, a prospective registry records all incident ALS cases among residents in Emilia Romagna (population: 4.4 million). For each patient, demographic and clinical details (including ALSFRS-R) are collected by caring physicians at each follow-up. Analysis was performed on 402 incident cases (1279 ALSFRS-R assessments). The average decline of the ALSFRS-R was 0.60 points/month during the first year after diagnosis and 0.34 points/month in the second year. ALSFRS-R decline was heterogeneous among subgroups. Repeated measures mixed model showed that ALSFRS-R score decline was influenced by age at onset (p < 0.01), phenotype (p = 0.01), body mass index (BMI) (p < 0.01), progression rate at diagnosis (ΔFS) (p < 0.01), El Escorial Criteria-Revised (p < 0.01), and FVC% at diagnosis (p < 0.01). Among these factors, at multivariate analysis, only age, site of onset and ΔFS independently influenced survival. In this first population-based study on ALSFRS-R trend, we confirm that ALSFRS-R decline is not homogeneous among ALS patients and during the disease. Factors influencing ALSFRS-R decline may not match with those affecting survival. These disease modifiers should be taken into consideration for trials design and in clinical practice during discussions with patients on prognosis.

Original languageEnglish
Pages (from-to)2243-2252
Number of pages10
JournalNeurological Sciences
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • ALSFRS-R
  • Amyotrophic lateral sclerosis
  • Disease progression
  • Heterogeneity
  • Population-based study

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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    Mandrioli, J., Biguzzi, S., Guidi, C., Sette, E., Terlizzi, E., Ravasio, A., Casmiro, M., Salvi, F., Liguori, R., Rizzi, R., Pietrini, V., Borghi, A., Rinaldi, R., Fini, N., Chierici, E., Santangelo, M., Granieri, E., Mussuto, V., De Pasqua, S., ... ERRALS Group (2015). Heterogeneity in ALSFRS-R decline and survival: a population-based study in Italy. Neurological Sciences, 36(12), 2243-2252. https://doi.org/10.1007/s10072-015-2343-6