Heterogeneity in colorectal cancer: A challenge for personalized medicine?

Chiara Molinari, Giorgia Marisi, Alessandro Passardi, Laura Matteucci, Giulia De Maio, Paola Ulivi

Research output: Contribution to journalReview article

Abstract

High inter-patient variability and high spatial heterogeneity are features of colorectal cancer (CRC). This may influence the molecular characterization of tumor tissue, now mandatory for patients with metastatic CRC who are candidates for treatment with an anti-EGFR mAb, as false-negative results can occur, leading to non optimal therapy. Moreover, temporal molecular heterogeneity during treatment is known to influence the response to therapy and prognosis. We present a literature overview of advances made in characterizing molecular heterogeneity in CRC, underlining that the analysis of liquid biopsy could represent an efficient non-invasive tool to overcome the problem. We believe that understanding CRC heterogeneity is fundamental for a more accurate diagnosis, for selecting the best targets to ensure prolonged antitumor response, and for monitoring minimal residual disease and the onset of resistance to therapy, all essential components of successful personalized treatment.

Original languageEnglish
Article number3733
JournalInternational Journal of Molecular Sciences
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

Fingerprint

Precision Medicine
Biopsy
medicine
Medicine
Tumors
Colorectal Neoplasms
cancer
Tissue
therapy
Monitoring
Liquids
prognosis
Therapeutics
Disease Resistance
tumors
Residual Neoplasm
liquids
Neoplasms

Keywords

  • cfDNA
  • Colorectal cancer
  • Heterogeneity
  • Liquid biopsy
  • Metastasis
  • Response to therapy
  • Tumor tissue

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Heterogeneity in colorectal cancer : A challenge for personalized medicine? / Molinari, Chiara; Marisi, Giorgia; Passardi, Alessandro; Matteucci, Laura; De Maio, Giulia; Ulivi, Paola.

In: International Journal of Molecular Sciences, Vol. 19, No. 12, 3733, 01.12.2018.

Research output: Contribution to journalReview article

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AU - Marisi, Giorgia

AU - Passardi, Alessandro

AU - Matteucci, Laura

AU - De Maio, Giulia

AU - Ulivi, Paola

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