Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression

Inès Martìn-Padura, Roberta Mortarini, Davide Lauri, Sergio Bernasconi, Francisco Sanchez-Madrid, Giorgio Parmiani, Alberto Mantovani, Andrea Anichini, Elisabetta Dejana

Research output: Contribution to journalArticle

Abstract

Tumor cell attachment to endothelial cells (EC) is one of the critical steps of the metastatic process. It was previously reported that interleukin 1 treatment of EC induces expression of membrane molecules that promote tumor cell adhesion. In this paper we report that a panel of six clones isolated from a human metastatic melanoma presented a marked heterogeneity in their ability to adhere to interleukin 1 activated EC. This was correlated with integrin VLA-4 expression by the clones. Antibodies directed to VLA-4 and to its endothelial ligand INCAM110/ VCAM-1 abolished interleukin 1 induced increase in melanoma cell adhesion to EC. These data demonstrate intratumor heterogeneity in the expression of VLA-4 and that this can represent a crucial determinant of tumor cell interaction with EC during secondary spread.

Original languageEnglish
Pages (from-to)2239-2241
Number of pages3
JournalCancer Research
Volume51
Issue number8
Publication statusPublished - Apr 15 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Martìn-Padura, I., Mortarini, R., Lauri, D., Bernasconi, S., Sanchez-Madrid, F., Parmiani, G., Mantovani, A., Anichini, A., & Dejana, E. (1991). Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression. Cancer Research, 51(8), 2239-2241.