Abstract
Surgically removed normal and malignant mammary tissues and human breast carcinoma cell lines were tested in binding assays with monoclonal antibodies to HLA-A,B,C antigens, β 2-microglobulin, HLA-DR antigens, and tumor-associated antigens; the latter included a Mr 280,000, a Mr 94,000, and a Mr 85,000 membrane-bound glycoprotein and a cytoplasmic antigen. HLA-A,B antigens, β 2-microglobulin, HLA-DR antigens, and the cytoplasmic antigen are expressed by normal mammary cells. Their malignant transformation may be associated with quantitative changes in the expression of these antigens and with the appearance of Mr 94,000 and Mr 85,000 glycoproteins. The Mr 280,000 glycoprotein was detected on only one of the breast carcinoma cell lines tested. Analysis of primary tumors and autologous axillary lymph node metastasis from 13 patients has shown differences in the expression of all the antigens tested between primary and metastatic lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 660-668 |
| Number of pages | 9 |
| Journal | Cancer Research |
| Volume | 43 |
| Issue number | 2 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells. / Natali, P. G.; Giacomini, P.; Bigotti, A.; Imai, K.; Nicotra, M. R.; Ng, A. K.; Ferrone, S.
In: Cancer Research, Vol. 43, No. 2, 1983, p. 660-668.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells
AU - Natali, P. G.
AU - Giacomini, P.
AU - Bigotti, A.
AU - Imai, K.
AU - Nicotra, M. R.
AU - Ng, A. K.
AU - Ferrone, S.
PY - 1983
Y1 - 1983
N2 - Surgically removed normal and malignant mammary tissues and human breast carcinoma cell lines were tested in binding assays with monoclonal antibodies to HLA-A,B,C antigens, β 2-microglobulin, HLA-DR antigens, and tumor-associated antigens; the latter included a Mr 280,000, a Mr 94,000, and a Mr 85,000 membrane-bound glycoprotein and a cytoplasmic antigen. HLA-A,B antigens, β 2-microglobulin, HLA-DR antigens, and the cytoplasmic antigen are expressed by normal mammary cells. Their malignant transformation may be associated with quantitative changes in the expression of these antigens and with the appearance of Mr 94,000 and Mr 85,000 glycoproteins. The Mr 280,000 glycoprotein was detected on only one of the breast carcinoma cell lines tested. Analysis of primary tumors and autologous axillary lymph node metastasis from 13 patients has shown differences in the expression of all the antigens tested between primary and metastatic lesions.
AB - Surgically removed normal and malignant mammary tissues and human breast carcinoma cell lines were tested in binding assays with monoclonal antibodies to HLA-A,B,C antigens, β 2-microglobulin, HLA-DR antigens, and tumor-associated antigens; the latter included a Mr 280,000, a Mr 94,000, and a Mr 85,000 membrane-bound glycoprotein and a cytoplasmic antigen. HLA-A,B antigens, β 2-microglobulin, HLA-DR antigens, and the cytoplasmic antigen are expressed by normal mammary cells. Their malignant transformation may be associated with quantitative changes in the expression of these antigens and with the appearance of Mr 94,000 and Mr 85,000 glycoproteins. The Mr 280,000 glycoprotein was detected on only one of the breast carcinoma cell lines tested. Analysis of primary tumors and autologous axillary lymph node metastasis from 13 patients has shown differences in the expression of all the antigens tested between primary and metastatic lesions.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020665445&partnerID=8YFLogxK
M3 - Article
C2 - 6336658
AN - SCOPUS:0020665445
VL - 43
SP - 660
EP - 668
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 2
ER -