Heterogeneity of axon terminals expressing VGLUT1 in the cerebral neocortex

F. Conti, C. Candiracci, G. Fattorini

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Abstract

Using immunocytochemical techniques and confocal microscopy we have studied the localization of the vesicular glutamate transporters (VGLUTs) 1 and 2 in the mammalian cerebral cortex. The cardinal observations gathered to date can be summarized as follows: 1) Many VGLUT1-positive puncta coexpressing synaptophysin-1 outline pyramidal cell somata and proximal dendrites; of these, a sizeable fraction coexpress VGAT, the vesicular transporter for GABA; 2) VGLUT2-positive puncta are also present in layers II-III and some of them coexpress VGLUT1. These findings suggest that in the cerebral cortex of adult rats axon terminals expressing VGLUT1 are heterogeneous.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalArchives Italiennes de Biologie
Volume143
Issue number2
Publication statusPublished - May 2005

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Neocortex
Presynaptic Terminals
Cerebral Cortex
Vesicular Glutamate Transport Protein 1
Vesicular Glutamate Transport Protein 2
Synaptophysin
Pyramidal Cells
Carisoprodol
Dendrites
Confocal Microscopy
gamma-Aminobutyric Acid
vesicular GABA transporter

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heterogeneity of axon terminals expressing VGLUT1 in the cerebral neocortex. / Conti, F.; Candiracci, C.; Fattorini, G.

In: Archives Italiennes de Biologie, Vol. 143, No. 2, 05.2005, p. 127-132.

Research output: Contribution to journalArticle

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