Heterogeneity of axon terminals expressing VGLUT1 in the cerebral neocortex

F. Conti, C. Candiracci, G. Fattorini

Research output: Contribution to journalArticlepeer-review


Using immunocytochemical techniques and confocal microscopy we have studied the localization of the vesicular glutamate transporters (VGLUTs) 1 and 2 in the mammalian cerebral cortex. The cardinal observations gathered to date can be summarized as follows: 1) Many VGLUT1-positive puncta coexpressing synaptophysin-1 outline pyramidal cell somata and proximal dendrites; of these, a sizeable fraction coexpress VGAT, the vesicular transporter for GABA; 2) VGLUT2-positive puncta are also present in layers II-III and some of them coexpress VGLUT1. These findings suggest that in the cerebral cortex of adult rats axon terminals expressing VGLUT1 are heterogeneous.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalArchives Italiennes de Biologie
Issue number2
Publication statusPublished - May 2005

ASJC Scopus subject areas

  • Medicine(all)


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