Heterogeneity of cortical lesions in multiple sclerosis

An MRI perfusion study

Denis Peruzzo, Marco Castellaro, Massimiliano Calabrese, Elisa Veronese, Francesca Rinaldi, Valentina Bernardi, Alice Favaretto, Paolo Gallo, Alessandra Bertoldo

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical lesions showed a statistically significant reduction in CBF and CBV compared with the normal-appearing gray matter, whereas there were no significant changes in the MTT. The reduced perfusion suggests a reduction of metabolism because of the loss of cortical neurons. A small population of outliers showing an increased CBF and/or CBV has also been detected. The presence of hyperperfused outliers may imply that perfusion could evolve during inflammation. These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Cerebrovascular Circulation
Multiple Sclerosis
Perfusion
Magnetic Resonance Imaging
Relapsing-Remitting Multiple Sclerosis
Inflammation
Neurons
Population
Cerebral Blood Volume

Keywords

  • brain imaging
  • cerebral blood flow
  • microglia
  • multiple sclerosis
  • perfusion-weighted MRI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Peruzzo, D., Castellaro, M., Calabrese, M., Veronese, E., Rinaldi, F., Bernardi, V., ... Bertoldo, A. (2013). Heterogeneity of cortical lesions in multiple sclerosis: An MRI perfusion study. Journal of Cerebral Blood Flow and Metabolism, 33(3), 457-463. https://doi.org/10.1038/jcbfm.2012.192

Heterogeneity of cortical lesions in multiple sclerosis : An MRI perfusion study. / Peruzzo, Denis; Castellaro, Marco; Calabrese, Massimiliano; Veronese, Elisa; Rinaldi, Francesca; Bernardi, Valentina; Favaretto, Alice; Gallo, Paolo; Bertoldo, Alessandra.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No. 3, 03.2013, p. 457-463.

Research output: Contribution to journalArticle

Peruzzo, D, Castellaro, M, Calabrese, M, Veronese, E, Rinaldi, F, Bernardi, V, Favaretto, A, Gallo, P & Bertoldo, A 2013, 'Heterogeneity of cortical lesions in multiple sclerosis: An MRI perfusion study', Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 3, pp. 457-463. https://doi.org/10.1038/jcbfm.2012.192
Peruzzo, Denis ; Castellaro, Marco ; Calabrese, Massimiliano ; Veronese, Elisa ; Rinaldi, Francesca ; Bernardi, Valentina ; Favaretto, Alice ; Gallo, Paolo ; Bertoldo, Alessandra. / Heterogeneity of cortical lesions in multiple sclerosis : An MRI perfusion study. In: Journal of Cerebral Blood Flow and Metabolism. 2013 ; Vol. 33, No. 3. pp. 457-463.
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