Abstract
In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical lesions showed a statistically significant reduction in CBF and CBV compared with the normal-appearing gray matter, whereas there were no significant changes in the MTT. The reduced perfusion suggests a reduction of metabolism because of the loss of cortical neurons. A small population of outliers showing an increased CBF and/or CBV has also been detected. The presence of hyperperfused outliers may imply that perfusion could evolve during inflammation. These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 457-463 |
| Number of pages | 7 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2013 |
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Keywords
- brain imaging
- cerebral blood flow
- microglia
- multiple sclerosis
- perfusion-weighted MRI
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Neurology
Cite this
Heterogeneity of cortical lesions in multiple sclerosis : An MRI perfusion study. / Peruzzo, Denis; Castellaro, Marco; Calabrese, Massimiliano; Veronese, Elisa; Rinaldi, Francesca; Bernardi, Valentina; Favaretto, Alice; Gallo, Paolo; Bertoldo, Alessandra.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No. 3, 03.2013, p. 457-463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heterogeneity of cortical lesions in multiple sclerosis
T2 - An MRI perfusion study
AU - Peruzzo, Denis
AU - Castellaro, Marco
AU - Calabrese, Massimiliano
AU - Veronese, Elisa
AU - Rinaldi, Francesca
AU - Bernardi, Valentina
AU - Favaretto, Alice
AU - Gallo, Paolo
AU - Bertoldo, Alessandra
PY - 2013/3
Y1 - 2013/3
N2 - In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical lesions showed a statistically significant reduction in CBF and CBV compared with the normal-appearing gray matter, whereas there were no significant changes in the MTT. The reduced perfusion suggests a reduction of metabolism because of the loss of cortical neurons. A small population of outliers showing an increased CBF and/or CBV has also been detected. The presence of hyperperfused outliers may imply that perfusion could evolve during inflammation. These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis.
AB - In this study, dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) was used to quantify the cerebral blood flow (CBF), the cerebral blood volume (CBV), and the mean transit time (MTT) and to analyze the changes in cerebral perfusion associated with the cortical lesions in 44 patients with relapsing-remitting multiple sclerosis. The cortical lesions showed a statistically significant reduction in CBF and CBV compared with the normal-appearing gray matter, whereas there were no significant changes in the MTT. The reduced perfusion suggests a reduction of metabolism because of the loss of cortical neurons. A small population of outliers showing an increased CBF and/or CBV has also been detected. The presence of hyperperfused outliers may imply that perfusion could evolve during inflammation. These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis.
KW - brain imaging
KW - cerebral blood flow
KW - microglia
KW - multiple sclerosis
KW - perfusion-weighted MRI
UR - http://www.scopus.com/inward/record.url?scp=84874657776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874657776&partnerID=8YFLogxK
U2 - 10.1038/jcbfm.2012.192
DO - 10.1038/jcbfm.2012.192
M3 - Article
C2 - 23250108
AN - SCOPUS:84874657776
VL - 33
SP - 457
EP - 463
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 3
ER -