Heterogeneity of dermal OKT6+ cells in inflammatory and neoplastic skin diseases

E. Berti, S. Cavicchini, M. Cusini, M. Monti, F. Parolini, R. Caputo

Research output: Contribution to journalArticlepeer-review


This immunopathologic study of both normal and pathologic skin specimens (contact dermatitis [CD], lichen planus [LP], cutaneous T cell lymphoma [CTCL], and histiocytosis X [HX]) allowed as to differentiate four types of dermal OKT6+ cells: (1) cells with the same morphologic features as epidermal Langerhans cells (LCs), rarely found in either normal or pathologic dermis; (2) cells structurally similar to LCs but lacking Birbeck granules (BGs), found mainly in CD and LP; (3) larger cells rich in cytoplasmic organelles, only 5% of which contained BGs. They were especially common CTCL; and (4) cells typical of HX.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalJournal of the American Academy of Dermatology
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Dermatology


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