Heterogeneity of human basophils and mast cells in response to muscle relaxants

C. Stellato, A. de Paulis, G. de Crescenzo, F. Tatangelo, O. Rickler, G. Marone

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the in vitro effects of increasing concentrations (10-5-10-3M) of four muscle relaxants (succinylcholine, d-tubocurarine, vecuronium and atracurium) on histamine release (HR) from human peripheral blood basophils and mast cells isolated from lung parenchyma (HLMC) and skin tissues (HSMC). Basophils released less than 5% of their histamine content when incubated with any one of the muscle relaxants. In contrast, mast cells showed a marked heterogeneity in their response. Succinylcholine did not induce HR from any type of mast cell, and only high concentrations of d-tubocurarine (10-3M) caused HR from HSMC and HLMC. Vecuronium concentration-dependently induced HR from HLMC and HSMC. Atracurium concentration-dependently caused marked HR from HLMC and HSMC up to a maximum of 46.2±15.1% and 30.6±6.0%, respectively. From both HLMC and HSMC HR caused by atracurium and vecuronium was extremely rapid (t1/2

Original languageEnglish
JournalAgents and Actions
Volume36
Issue number2 Supplement
DOIs
Publication statusPublished - Jun 1992

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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