Heterogeneity of large granular lymphocyte proliferations: Morphological, immunological and molecular analysis in seven patients

F. Lauria, R. Foa', N. Migone, M. C. Giubellino, D. Raspadori, M. Buzzi, G. Casorati, M. Gobbi, P. L. Tazzari, S. Tura

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical, morphological, immunological and molecular features of seven patients with a stable picture of chronic granular lymphocytosis, observed over a period of up to 4 years, were studied. Mild splenomegaly was detected in one patient, while lymphoadenopathy and hepatomegaly were absent. Surface marker analysis showed in five patients the common membrane phenotype of granular T-cell lymphocytosis (T3+, T4-, T8+, Leu-7+); of the remaining two, one presented an unusual phenotype (T3+, T4+, T8+) and the other showed a marked positivity with the Leu-11 and M1 monoclonal antibodies, but lacked the T3, T4, T8 antigens. Three cases had a low (

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalBritish Journal of Haematology
Volume66
Issue number2
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Hematology

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