Heterogeneity of progressive fluent aphasia; two cases analysis

S. Avanzi, S. Maier, Cavatoria Su, D. Perani, P. Caffarra, A. Mazzucchi

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Two case reports are presented (LR, 49 years old woman, and PA, 62 year old man) who in 1995 came to our observation for a 2-yearperiod of word-finding difficulties. In both patients case history was unremarkable, while on longitudinal evaluation a progressive impairment of the lexical-semantic aspects of language was found. However, LR's deficits In naming and word comprehension appear to be the result of a profound breakdown of semantic knowledge, whercas in PA we between semantic and phonological output system. General intelligence, non-lexical aspects of language and visual perception were spared. Both patients are still autonomous in every day-life. Different evolution of progressive fluent aphasia, MRI sites of focal cortical atrophy, PET data anti implications to the cognitive model of semantic memory are discussed.

Original languageEnglish
Pages (from-to)117
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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