Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans

Panithaya Chareonthaitawee, Philipp A. Kaufmann, Ornella Rimoldi, Paolo G. Camici

Research output: Contribution to journalArticle

Abstract

Objective: Absolute myocardial blood flow (MBF) is not well-defined in large normal populations, and appears to be heterogeneous in both humans and animals. These factors contribute to the difficulties in defining resting MBF to hibernating myocardium. We therefore assessed absolute baseline and hyperemic MBF in a large population of normal humans. Methods: MBF was quantified by positron emission tomography with oxygen-15-labeled water at baseline and during hyperemia induced by either adenosine or dipyridamole in 131 men and 38 women, aged 21-86 (mean 46±12) years. MBF was corrected for workload using the rate-pressure product (RPP). Results: Uncorrected baseline MBF ranged from 0.590 to 2.050 (mean 0.985±0.230) ml/min/g (coefficient of variation=27%), and corrected MBF from 0.736 to 2.428 (mean 1.330±0.316) ml/min/g (coefficient of variation=24%). MBF in the inferior region was significantly (P

Original languageEnglish
Pages (from-to)151-161
Number of pages11
JournalCardiovascular Research
Volume50
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Adenosine
  • Blood flow
  • Coronary circulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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